张秀辉

异甘草酸镁在肝癌射频消融术后肝损伤中的应用研究

张秀辉

目的探讨异甘草酸镁对改善肝癌射频消融术后肝损伤的临床价值。方法选取2013年4月至2014年6月收治的原发性肝癌86例为研究对象，随机分为两组，每组43例，所有患者均接受肝癌射频消融术治疗。观察组术后给予异甘草酸镁，对照组术后给予甘草酸二铵，观察两组患者术前与术后1 d、7 d肝功能相关指标变化。结果两组术前ALT、AST、TBIL无明显差异（P＞0.05），术后1 d上述指标均明显上升，术后7 d观察组ALT、AST、TBIL水平明显低于对照组，差异有统计学意义（P＜0.05）；两组患者术前ALB、TP无明显差异（P＞0.05），术后均明显降低（P＜0.05），术后1 d、7 d两组患者ALB、TP无显著差异（P＞0.05）。结论异甘草酸镁对肝癌射频消融术后肝损伤具有明显保护作用，能有效减少不良反应，提高患者生存质量，值得推广。

肝癌；射频消融术；肝损伤；异甘草酸镁

【Abstract】Objective To explore the effect of magnesium isoglycyrrhizinate on patients with liver cancer after radiofrequency ablation.Method Through April 2013 to June 2014,86 patients with primary liver cancer were randomly assigned into two groups with 43 cases in each group.All patients were treated with radiofrequency ablation.Observation group was treated with magnesium isoglycyrrhizinate postoperatively, while the control group was treated with diammonium glycyrrhizinate.The liver function was detected before the operation,and the 1st and 7th day after the operation.Results Preoperative ALT,AST,TBIL level had no significant difference between two groups(P>0.05).On the 1st day after the operation,ALT,AST,TBIL were significantly increased,and on the 7th day ALT,AST,TBIL level in observation group was significantly lower than that in the control group(P<0.05).ALB and TP level had no significant difference between two groups before the operation(P>0.05).After the operation,ALB and TP were significantly decreased(P<0.05),with a statistical insignificant difference between 1st day and 7th day(P>0.05).Conclusion Magnesium isoglycyrrhizinate has a protective effect on patients with liver cancer after receiving radiofrequency ablation,and it can effectively reduce the adverse reaction and improve the quality of life of patients.

【Key words】Liver cancer;Radiofrequency ablation;Liver injury;Magnesium isoglycyrrhizinate

肝癌是临床中较为常见的恶性肿瘤，其发展较快，恶性程度高，严重危害患者健康及生命，需采取有效方法进行诊治。随着医疗技术的不断发展，肝癌治疗从单纯手术切除、化疗、放疗发展为多种手段相结合的治疗模式。射频消融技术的出现，为肝癌的临床治疗提供了新的途径。肝癌射频消融术具有创伤小、疗效确切、重复性强等优势，在临床得到广泛应用。但有学者指出[1]，患者在接受射频消融术治疗后，肝功能会受到不同程度损害，严重者可出现肝功能衰竭，因此在治疗过程中选择有效保肝药物，对提高疗效，改善预后具有重要作用。本……