罗会俊　朱淑芳　王小毛　张才友

1.江西省赣州市肿瘤医院药剂科，江西赣州　341000；2.江西省赣州市肿瘤医院放疗科，江西赣州　341000

奥美拉唑治疗小儿上消化道出血疾病的临床效果及安全性分析

罗会俊1朱淑芳2王小毛1张才友1

1.江西省赣州市肿瘤医院药剂科，江西赣州341000；2.江西省赣州市肿瘤医院放疗科，江西赣州341000

目的观察分析奥美拉唑治疗小儿上消化道出血疾病的临床效果及安全性。方法将我院在2014年3月～2015年2月收治的110例小儿上消化道出血疾病的患儿作为研究对象，采用随机数字法分为对照组55例和观察组55例，对照组采用西咪替丁治疗，观察组采用奥美拉唑治疗，比较两组患儿的治疗效果、临床症状改善时间、止血时间、住院时间及不良反应的发生情况。 结果观察组总有效率为94.6%，对照组总有效率为80.0%，观察组总有效率明显高于对照组，差异具有统计学意义（P＜0.05）；观察组患儿的临床症状改善时间、止血时间、住院时间明显短于对照组，差异具有统计学意义（P＜0.05）；观察组不良反应发生率为5.5%，对照组不良反应发生率为18.2%，观察组患儿不良反应发生率明显低于对照组，差异具有统计学意义（P＜0.05）。结论奥美拉唑治疗小儿上消化道出血疾病的临床效果显著，有效改善患儿的临床症状，且不良反应发生率低，安全可靠，值得在临床上应用及推广。

奥美拉唑；小儿上消化道出血；安全性

［Abstract］Objective To observe and analyze the clinical effects and safety of omeprazole in treatment of children with upper gastrointestinal bleeding.M ethods 110 children with upper gastrointestinal bleeding and who accepted treatments in our hospital from March 2014 to February 2015 were taken as the research objects，and were randomly divided into the control group of 55 cases and the observation group of 55 cases by the random numbermethod.In the control group were treated with the cimetidine while in the observation group were treated with the omeprazole.Then，the treatment effect，the improvement time of clinical symptoms，hemostasis time，hospitalization time and the incidence of adverse reactions of the two groups were compared.Results The total effective rate in the observation group was 94.6%，and the total effective rate in the control group was 80.0%，while the total effective rate in the observation group was significantly higher than that of control group，and the difference was statistically significant（P＜0.05）；The improvement of the clinical symptoms time，hemostasis time，hospitalization time in the observation group were significantly shorter than those in the control group，the difference was statistically significant（P＜0.05）；In addition，the incidence of adverse reactions in the observation group was 5.5%，and the incidence of adverse reactions in the control group was 18.2%，while the incidence of adverse reactions in the observation group was significantly lower than that of the control group，and the differencewas statistically significant（P＜0.05）.Conclusion The clinical effect of omeprazole in treatment of children with upper gastrointestinal bleeding are significant，which can effectively improve the patients of clinical symptoms，and the incidence of adverse reactions is low，safety and reliable，thus it isworthy to be applied and promoted in the clinical.

［Key words］Omeprazole；Children with upper gastrointestinal bleeding；Safety

小儿消化道出血是临床上常见的高危疾病，该病起病急，病情发展速度快，短时间内可发生大出血，导致引发多种并发症，若不及时进行止血，大量出血引起患儿失血性休克，甚至死亡，严重威胁着患儿的生命安全［1］。……