傅丽敏　程　雪　张小薇

1.浙江省丽水市中心医院检验科，浙江丽水　323000；2.浙江省丽水市中心医院放射科，浙江丽水　323000

血清肿瘤标记物癌胚抗原、CA153和CA125检测对乳腺癌的临床诊断价值

傅丽敏1程雪2▲张小薇1

1.浙江省丽水市中心医院检验科，浙江丽水323000；2.浙江省丽水市中心医院放射科，浙江丽水323000

目的探讨血清肿瘤标记物癌胚抗原（CEA）、糖类抗原153（CA153）和糖类抗原125（CA125）检测对乳腺癌的临床诊断价值。方法选取乳腺癌患者144例（实验组），健康查体者144例（对照组），采集空腹静脉血样本，运用化学发光法检测实验组、对照组血清CEA、CA153和CA125的水平，采用SPSS 20.0统计学软件进行数据整理分析。结果 实验组患者外周血清中肿瘤标记物CEA、CA153和CA125的检测值 ［分别为：（6.52±2.81）ng/ mL、（43.94±4.29）U/mL、（35.17±4.01）U/mL）］高于对照组［分别为：（2.35±0.64）ng/mL、（18.01±3.08）U/mL、（22.75±3.36）U/ mL］（P＜0.05）；实验组阳性率（分别为：6.25%、11.81%、7.64%）高于对照组（P＜0.05）；三种肿瘤标记物联合检测时阳性率为34.03%。联合检测与单项指标检测相比，敏感性明显提高。 结论检测血清中肿瘤标记物CEA、CA153和CA125能提高乳腺癌的诊断率，有助于乳腺癌的早发现，同时有助于有效预防该病的复发，在乳腺癌临床诊断中具有重要意义，值得临床普及和应用。

乳腺癌；肿瘤标志物；癌胚抗原；糖类抗原153；糖类抗原125

［Abstract］Objective To evaluate the clinical significance of earicnoembryonic antigen（CEA），CA153 and CA125 detection in clinical treatment of breast cancer.M ethods A total of 144 patients suffering from breast cancer（experimental group）and 144 healthy volunteers（control group）were selected.Serum levels of CEA，CA153 and CA125 were determined in experimental group，control group by chemiluminescentmethod，and the data were statistical analyzed by using SPSS 20.0 statistical software.Results The levels of CEA，CA153 and CA125 of the experimental group［（6.52± 2.81）ng/mL，（43.94±4.29）U/mL and（35.17±4.01）U/mL］were significant higher than that of the control group［（2.35± 0.64）ng/mL，（18.01±3.08）U/mL，（22.75±3.36）U/mL］（P＜0.05）.The sensitivity of breast cancer by detecting the three serum markerswas 6.25%，11.81%and 7.64%respectively，which wasmuch higher than the control group（P＜0.05）and lower than that detected by the combined assay.The sensitivity of breast cancer detected by three serum markers combined assay was 34.03%.Compared with the single serum marker detection，the sensitivity of combined assay was significantly improved.Conclusion The detection of serum marker CEA，CA153 and CA125 can improve the diagnostic rate of breast cancer.The levels of CEA，CA153 and CA125 can provide reference for the early diagnosis of breast cancer as well as the recurrence of breast cancer.It is of great significance in the clinical diagnosis of breast cancer，worthy of clinical popularization and application.

［Key words］Breast cancer；Tumormarkers；CEA；CA153；CA125

乳腺癌在生物学上具有高度异质性，其发病率居所有女性恶性肿瘤的首位，而且仍呈逐年升高的趋势［1，2］，是当今妇女最常见的恶性肿瘤之一［3］。对于这种疾病如果能够及早发现，及早进行诊断治疗，就会将疾病的治愈率显著提高，也会降低医疗费用，缓解患者的家庭负担，使生活质量和生存率都有较大提高［4］。……