王庆熙　吴赛珍浙江省乐清市人民医院神经内科，浙江乐清　325600

超敏C反应蛋白和血清铁蛋白与脑出血患者预后的相关性研究

王庆熙吴赛珍
浙江省乐清市人民医院神经内科，浙江乐清325600

目的探讨不同出血量脑出血患者的超敏C反应蛋白和血清铁蛋白水平变化情况及与预后的相关性。方法研究对象选取2015年1月～2016年1月我院神经内科收治的120例基底节区脑出血住院患者，根据脑出血量分为少量出血组（＜10mL）、中量出血组（10～20mL）、大量出血组（＞20mL）各40例，并选取同期健康体检者50例作为对照组，分别测定患者发病第1天、第3天、第14天的超敏C反应蛋白（hs-CRP）和血清铁蛋白水平，治疗结束后采用美国国立卫生院卒中量表（NIHSS）评估患者的神经功能缺损情况，评价患者神经功能缺损与血清hs-CRP、铁蛋白水平的相关性。 结果脑出血患者发病后各时间点的血清hs-CRP、铁蛋白水平均显著高于对照组，差异具有统计学意义（P＜0.05）；出血量越大的脑出血患者血清hs-CRP、铁蛋白水平相对越高，各组间比较差异均存在统计学意义（P＜0.05）；神经功能缺损患者第14天时血清hs-CRP水平显著高于无神经功能缺损患者（P＜0.05），但血清铁蛋白水平比较差异无统计学意义（P＞0.05）。结论超敏C反应蛋白和血清铁蛋白水平能够一定程度上反映脑出血的进展和程度，脑出血量越大则患者的超敏C反应蛋白和血清铁蛋白水平改变越显著，但仅超敏C反应蛋白具有预后评估价值。

脑出血；超敏C反应蛋白；血清铁蛋白；预后

［Abstract］Objective To explore the correlation between high sensitivity C-reactive protein（hs-CRP），serum ferritin and prognosis of patientswith cerebral hemorrhage of different volumes.M ethods A total of 120 patientswith cerebral hemorrhage in basal ganglia treated in our department from January 2015 to January 2016 were selected and divided according to the volumes of bleeding intomild group（＜10mL），moderate group（10-20mL），and severe group（＞20mL），each with 40 cases；another 50 cases of healthy volunteers were also selected as control group.The levels of hs-CRP and serum ferritin at day 1，day 3，and day 14 of disease onsetwere determined.After treatment，the patientswere assessed by NIHSS for their neurologic impairment and the correlation between neurologic impairment and levels of hs-CRP and serum ferritin were analyzed.Results The levels of hs-CRP and serum ferritin were significantly higher in patientswith cerebral hemorrhage than that in the control group at each time point（P＜0.05）.The levels of hs-CRP and serum ferritin were higher in patients with larger volume of bleeding than those with smaller volume and the intergroup comparisonswere significant（P＜0.05）.The levels of hs-CRPwere significantly higher in patients with neurologic impairment than in those without neurologic impairment（P＜0.05），but levels of serum ferritin showed no significant difference in this indicator（P＞0.05）.Conclusion Levels of hs-CRP and serum ferritin can indicate the progress and degree of cerebral hemorrhage to some extent，and the changes of hs-CRP and serum ferritin levels aremore significant in patientswith larger volume of hemorrhage，but only hs-CRP is valuable for prognosis evaluation.

［Key words］Cerebral hemorrhage；High sensitivity C-reactive protein；Serum ferritin；Prognosis

脑出血是临床常见的一类神经内科疾病，具有发病急、进展快、病情重、致残率高、致死率高的特点。……