陈　裕范晓飞郑忠青　王邦茂

天津医科大学总医院消化科(300052)



薄荷素油对家兔Oddi括约肌收缩性的影响

陈裕*范晓飞*郑忠青王邦茂#

天津医科大学总医院消化科(300052)

背景：薄荷素油具有直接松弛消化道平滑肌、利胆等作用。Oddi括约肌作为消化道平滑肌的一部分，具有自主收缩和舒张运动功能，对胆汁排出具有重要意义。目的：探讨薄荷素油对家兔Oddi括约肌收缩性的影响。方法：20只家兔随机分为实验组和对照组，分别向Oddi括约肌处喷洒5 mL薄荷素油溶液或0.9% NaCl溶液，动态监测Oddi括约肌收缩和压力变化。结果：实验组喷洒薄荷素油溶液后，Oddi括约肌基础压[(10.600±1.712) mm Hg对(17.500±1.581) mm Hg，P<0.01]、收缩频率[(6.700±0.823)次/min对(9.000±1.247)次/min，P<0.01]和运动指数[(50.400±10.068) mm Hg·次/min对(67.500±19.021) mm Hg·次/min，P<0.01]较基线值显著降低，收缩幅度则无明显变化[(7.500±1.080) mm Hg对(7.400±1.264) mm Hg，P>0.05]；对照组喷洒0.9% NaCl溶液前后上述各项指标差异均无统计学意义(P>0.05)。结论：薄荷素油可能通过抑制Oddi括约肌收缩、降低Oddi括约肌基础压而降低胆汁排出阻力，从而发挥利胆、预防胆固醇结石形成的作用。

薄荷素油；奥狄括约肌；测压法；利胆

Correspondence to:WANG Bangmao,Email:gi.tmuh@sohu.com

Background:Peppermint oil can inhibit directly the gastrointestinal smooth muscle contraction and facilitating the bile discharge.As a part of digestive tract smooth muscles,sphincter of Oddi is important for gallbladder emptying by its spontaneous systolic and diastolic motor function.Aims:To investigate the effect of peppermint oil on contractility of sphincter of Oddi in rabbits.Methods:Twenty rabbits were randomly divided into experimental group and control group,and received the spraying of 5 mL peppermint oil or normal saline at sphincter of Oddi,respectively.Alterations in contraction of sphincter of Oddi and its basal pressure were monitored dynamically.Results:In experimental group,the basal pressure [(10.600±1.712) mm Hg vs.(17.500±1.581) mm Hg,P<0.01],contraction frequency [(6.700±0.823) times/min vs.(9.000±1.247) times/min,P<0.01] and motor index of sphincter of Oddi [(50.400±10.068) mm Hg·times/min vs.(67.500±19.021) mm Hg·times/min,P<0.01] were significantly decreased after spraying of peppermint oil,but no significant change in contraction amplitude was found [(7.500±1.080) mm Hg vs.(7.400±1.264) mm Hg，P>0.05].While in control group,all the above-mentioned parameters were stable after spraying of normal saline (P>0.05).Conclusions:Peppermint oil may facilitate the discharge of bile from gallbladder and prevent cholesterol calculus formation by reducing the contraction of sphincter of Oddi and its basal pressure and subsequently decreasing the resistance of bile discharge.

胆囊的张力和运动依赖于胆囊平滑肌的收缩，Oddi括约肌是控制胆汁排出胆道的惟一门户，对胆囊充盈、胆汁排出以及胆道系统正常压力的维持等具有重要意义。作为胆道动力学研究的热点，Oddi括约肌功能的研究方法众多，包括B超、MRCP、放射性核素扫描、电生理学检查、Oddi括约肌测压等，其中Oddi括约肌测压是公认的研究Oddi括约肌功能的金标准。薄荷素油(peppermint oil)为薄荷的挥发油，主要成分有薄荷醇、薄荷酮、异薄荷酮等。作为一种传统中草药，薄荷素油具有清凉止痒、解痉、抗炎、镇痛等作用，常被用于治疗恶心、肠易激综合征以及作为结肠镜检查的解痉剂。近年……