张明华北理工大学附属医院急诊科，河北唐山　063000

老年糖尿病并发周围神经功能紊乱的临床观察

张明
华北理工大学附属医院急诊科，河北唐山063000

目的 观察并分析老年糖尿病并发周围神经紊乱的临床治疗效果。方法 选取该院在2013年10月—2015年10月收治的150例老年糖尿病足并发周围神经病变的患者作为研究对象，将所有患者按照随机法划分为观察组和对照组，每组75例。对照组患者单纯采用前列地尔进行治疗，观察组患者采用前列地尔配合α-硫辛酸注射液进行治疗，对两组患者的治疗效果进行观察并做比较。结果 两组患者干预前后的踝肱指数、空腹血糖、餐后2 h血糖、糖化血红蛋白相较均有差异，但观察组患者的干预后与干预前相比，差异有统计学意义（P＜0.05）；对比两组患者的多伦多临床神经病变（TCSS）评分，差异有统计学意义（P＜0.05）。结论 临床上对于老年糖尿病并发周围神经病变的患者，采用前列地尔联合α-硫辛酸注射液进行治疗，效果更好，能够提高患者的恢复，值得推广使用。

老年糖尿病；周围神经功能紊乱；前列地尔

DOI：10.16658/j.cnki.1672-4062.2016.10.003

［Abstract］Objective To observe and analyze the clinical treatment effect of elderly diabetes complicated by peripheral nerve function disorder.Methods 150 cases of elderly patients with diabetes complicated by peripheral nerve function disorder admitted and treated in our hospital from October 2013 to October 2015 were selected as the research object and randomly divided into two groups with 75 cases in each,the control group were treated with simple alprostadil,the observation group were treated with alprostadil and alpha thioctic acid injection,the treatment effects of the two groups were observed and compared.Results There were differences in the ankle-brachial index,fasting blood-glucose,2h postprandial blood glucose？and glycosylated hemoglobin before and after intervention between the two groups,but the differences in the observation group after intervention were more obvious than those before intervention with statistical significance（P＜0.05）,the difference in the Toronto clinical nerve function disorder scoring between the two groups was obvious with statistical significance（P＜0.05）.Conclusion The effect of alprostadil and alpha thioctic acid injection in treatment of elderly patients with diabetes complicated by peripheral nerve function disorder in clinic is better,which can improve the recovery of patients, and it is worth promotion and application.

［Key words］Elderly diabetes；Peripheral nerve function disorder；Alprostadil

临床上糖尿病是一种严重的疾病，这种疾病对患者的正常生活带来较大影响，而且容易引发各类并发症，其中糖尿病周围神经病变便是其中一种较为常见也是较为麻烦的并发症［1］，其发病率较高，为患者带来不小的困扰［2］。糖尿病周围神经病变的主要临床症状是患者产生不同程度的感觉障碍，而且患者会有一定程度的对称性疼痛和感觉异常等情况。……