叶佳乐　钱彩华　王　斌　陆华东

浙江省湖州市中心医院呼吸内科，浙江湖州　313000

全程护理干预对自体DC/CIK细胞维持治疗的肺腺癌患者的临床疗效分析

叶佳乐钱彩华王斌陆华东▲

浙江省湖州市中心医院呼吸内科，浙江湖州313000

目的分析全程护理干预对自体DC/CIK细胞维持治疗的肺腺癌患者的临床疗效。方法选择2014年4月～2015年6月我院呼吸内科接诊的60例自体DC/CIK细胞治疗的肺腺癌患者作为研究对象。按照随机法将患者分为观察组和对照组，各30例。对照组在维持治疗后给予常规护理干预，观察组在对照组常规护理干预的基础上给予全程护理干预。复查患者肝肾功能，比较两组护理前后肝、肾功能检测指标变化、临床疗效及护理满意度。结果两组患者护理干预后，ALT、AST水平均降低，对照组TBIL水平降低，观察组TBIL水平下降。护理后两组患者的肝功能检测差异具有统计学意义（P＜0.05）。护理后，两组患者CysC、SCr、CCr肾功能检测指标变化差异有统计学意义（P＜0.05）。观察组患者总缓解率为83.33%，明显高于对照组的36.67%，两组患者临床疗效差异有统计学意义（P＜0.05）。对照组总满意率为63.33%，观察组总满意率为90.00%，两组患者护理满意度差异有统计学意义（P＜0.05）。结论全程护理干预自体DC/CIK细胞治疗的肺腺癌患者后，患者肝肾功能影响小，临床疗效显著，取得较高护理满意度，该种护理模式值得在临床广泛应用推广。

免疫治疗；DC/CIK细胞；肺腺癌；肝肾功能；全程护理干预

［Abstract］Objective To analyze the clinical curative effects of whole course nursing intervention on autologous DC/ CIK cellsmaintenance therapy for patients with lung adenocarcinoma.M ethods 60 patientswith lung adenocarcinoma treated with autologous DC/CIK cellswhowere admitted to the Departmentof Respiratory Medicine in our hospital from April 2014 to June 2015 were selected as research subjects.The patientswere evenly assigned to the observation group and the control group according to the randomization method，with 30 patients in each group.The control group was given regular nursing intervention aftermaintenance therapy，and the observation group was given whole course nursing intervention on the basis of regular nursing intervention.Patient's liver and kidney functions were re-examined. Changes of test indicators of liver and kidney functions，clinical effects and nursing satisfaction degree before and after nursing were compared between the two groups.Results After nursing intervention in the two groups of patients，the levels of ALT and AST both decreased.The TBIL levelwas decreased in the control group，and the TBIL level was reduced in the observation group.There was statistical difference of liver function between the two groups of patients after nursing（P＜0.05）.After nursing，the difference of changes of indicators of liver function CsyC，SCr，CCrwas significant （P＜0.05）.The overall remission rate in the observation group was 83.33%，significantly higher than that of 36.67%in the control group.The difference of clinical effects between the two groupswas significant（P＜0.05）.The overall satisfaction grate in the control group was 63.33%，and the overall satisfaction rate in the observation group was 90.00%. The difference of satisfaction rate between the two groups was significant（P＜0.05）.Conclusion After comprehensive nursing intervention for patientswith lung adenocarcinoma treated by autologous DC/CIK cellsmaintenance therapy the effects on liver and kidney functions areminor，the clinical effects are significant，and the nursing satisfaction rate is higher.Therefore this nursingmode isworthy of clinicalwidespread application and promotion.

［Key words］Immunotherapy；DC/CIK cells；Lung adenocarcinoma；Liver and kidney function；Whole course nursing intervention

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通讯作者

据相关数据部门统计［1］，全球最常见癌症当属肺癌，其中60%肺癌患者在确诊时已属晚期。……