赵　雷山东省菏泽市第三人民医院神经内科，山东菏泽　274000

托拉塞米和呋塞米治疗脑出血后急性脑水肿疗效的比较研究

赵雷
山东省菏泽市第三人民医院神经内科，山东菏泽274000

目的探讨托拉塞米和呋塞米在治疗脑出血后急性脑水肿的临床效果。方法选取我院2014年9月～2015年4月诊治的脑出血后急性脑水肿患者156例，根据治疗方法的不同将患者分为研究组和对照组各78例，研究组患者选择托拉塞米结合甘露醇进行治疗，对照组患者选择呋塞米结合甘露醇进行治疗，比较两组患者的治疗效果和并发症出现情况。结果研究组的总有效率94.9%，对照组为71.8%，研究组患者治疗的效果更好（P＜0.05）；研究组患者中有7例出现并发症，对照组有19例，研究组患者的安全性更高（P＜0.05）。结论在脑出血后急性脑水肿的治疗中，托拉塞米的治疗效果明显好于呋塞米，其可以缓解患者的临床症状，且治疗并发症少，安全性高，有着积极的临床治疗价值。

托拉塞米；呋塞米；脑出血；急性脑水肿

［Abstract］Objective To compare and analyze the clinical effects of torasemide and furosemide in treatment of acute cerebral edema after cerebral hemorrhage.M ethods 156 patients with acute cerebral edema after cerebral hemorrhage treated in our hospital from September 2014 to April 2015 were selected and divided based on treatment into study group and control group，each with 78 cases.Patients in the study group were given torasemide plusmannitol，while those in the control group were given furosemide plusmannitol.The effects and incidence rates of complications were compared between two groups.Results The overall response rate was 94.9%in the study group，and 71.7%in the control group，which was significantly higher in the study group（P＜0.05）.7 cases of complications were observed in the study group，and 19 cases in the controlgroup，showing higher safety of the study group（P＜0.05）.Conclusion Torasemide has significant favorable effect than furosemide in treatment of acute cerebral edema after cerebral hemorrhage，which can relieve the clinical symptoms of patients，with low incidence of complications and high safety，showing positive value in clinical treatment.

［Key words］Torasemide；Furosemide；Cerebral hemorrhage；Acute cerebral edema

脑出血是脑卒中疾病的一种，患者脑内血管出现破裂，由脑血管发病而引起，有着较高的死亡率和致残率。脑出血患者通常有很多并发症，其中最为常见的一种就是急性脑水肿疾病，患者脑部的水肿增加，脑部容积增大，若没有得到及时的治疗，会导致患者的死亡［1］。当前临床上治疗脑出血后急性脑水肿的主要原则为脱水、利尿，采用的药物主要有托拉塞米和呋塞米等［2］，其药物效果不一。本文对两种药物的治疗效果进行了对比分析，观察其临床治疗效果和安全性，为临床治疗提供参考，现报道如下。……