厄贝沙坦联合氨氯地平治疗高血压糖尿病肾病的疗效

2016-08-17张露肖永芬

糖尿病新世界 2016年13期

关键词：高血压糖尿病疗效

张露，肖永芬

临沂经济技术开发区医院药剂科，山东临沂276023

论著

厄贝沙坦联合氨氯地平治疗高血压糖尿病肾病的疗效

张露，肖永芬

临沂经济技术开发区医院药剂科，山东临沂276023

目的对厄贝沙坦联合氨氯地平治疗高血压糖尿病肾病的疗效进行研究。方法以数字随机法将该院收治的70例高血压糖尿病肾病患者分为观察组和对照组，给予观察组厄贝沙坦联合氨氯地平治疗，给予对照组厄贝沙坦单药治疗，将两组治疗前后的血压和尿液检查相关指标变化情况。结果治疗前，两组的收缩压、舒张压和24 h尿白蛋白、24 h尿蛋白定量、尿β2-微球蛋白差异无统计学意义（P＞0.05）。治疗后，观察组的收缩压、舒张压得到显著改善，且24 h尿白蛋白、24 h尿蛋白定量、尿β2-微球蛋白也得到显著降低，与对照组相比，差异有统计学意义（P＜0.05）。结论厄贝沙坦联合氨氯地平在控制血压、减轻肾损伤等方面具有明显优势，值得推广。

厄贝沙坦；氨氯地平；高血压糖尿病肾病；血压；肾损伤

［Abstract］Objective To research the curative effect of irbesartan and am lodipine in treatment of hypertension patients with diabetic nephropathy.M ethods 70 cases of hypertension patients with diabetic nephropathy admitted and treated in our hospital were randomly divided into two groups，the observation group were treated with irbesartan and am lodipine，the control group were treated with single irbesartan，and the changes of blood pressure and indicators in relation to urine examination of the two groups before and after treatment were observed.Resu lts Before treatment，the differences in the systolic pressure and diastolic pressure，24h urinary albumin，24h urine protein quantitation and urineβ-microglobulin were not obvious（P＞0.05），after treatment，the systolic pressure and diastolic pressure in the observation group were obviously improved，and the 24h urinary albumin，24h urine protein quantitation and urineβ-macroglobulin obviously decreased，and the differences were obvious compared with those in the control group（P＜0.05）.Conclusion Irbesartan and am lodipine has an obvious advantage in controlling blood pressure and reliving renal injury，which isworth promotion.

［Key words］Irbesartan；Am lodipine；Hypertension patientswith diabetic nephropathy；Blood pressure；Renal injury

目前，临床上应对高血压糖尿病肾病患者用药方案的选择予以重视，力争既能达到理想的疗效，又能保护肾脏免受损害［1］。在该研究中，该院为能给临床研究提供更多的帮助，特对2015年3月—2016年2月收治的两组共70例高血压糖尿病肾病患者实施厄贝沙坦联合氨氯地平治疗与厄贝沙坦单药治疗，并对比两种用药方案的应用价值，现报道如下。