曹嫚

【摘要】 目的：探讨并观察布拉酵母菌散剂在治疗小儿消化不良性腹泻方面所具有的临床效果及安全性。方法：选取2012年1月-2015年1月于笔者所在医院进行腹泻治疗的198例患儿作为研究对象，将其随机分为治疗组和对照组，对照组98例采用常规对症治疗，口服密斯达、静脉滴注利巴韦林等，治疗组100例患儿在对照组基础上给予布拉酵母菌散剂进行治疗，两组患儿均连续治疗7 d，并进行持续观察，然后将两组患儿的临床效果及不良反应发生率进行统计及分析。结果：治疗组中显效72例，有效24例，总有效率为96.0%；对照组显效47例，有效30例，总有效率为78.6%，治疗组疗效优于对照组，差异有统计学意义（P<0.05）。将两组患儿各项症状的恢复时间进行统计及比较，治疗组发热患儿体温恢复正常时间（3.18±0.46）d，呕吐缓解时间（1.02±0.44）d，腹痛缓解时间（1.09±1.08）d和排便恢复正常时间（3.14±0.24）d，均明显短于对照组的体温恢复正常时间（4.25±0.48）d，呕吐缓解时间（1.52±0.63）d，腹痛缓解时间（1.89±1.27）d，排便恢复正常时间（5.97±0.98）d，差异均有统计学意义（P<0.05）；两组不良反应发生率对比差异无统计学意义（P>0.05）。结论：小儿消化不良性腹泻采用布拉酵母菌散剂治疗效果比较明显，显著提高了疗效，同时不但能够有效地缓解临床症状，而且具有较高的安全性，值得临床推广应用。

【关键词】 布拉酵母菌散剂； 小儿消化不良性腹泻； 临床疗效观察

中图分类号 R725.7 文献标识码 A 文章编号 1674-6805（2016）9-0003-02

【Abstract】 Objective：To investigate and observe the safety and clinical effect of Saccharomyces Boulardii Powder in the treatment of infantile indigestion diarrhea.Method：198 cases with infantile indigestion diarrhea in our hospital from January 2012 to January 2015 were selected as the research objects，they were randomly divided into the treatment group and the control group，98 cases in the control group were treated with conventional symptomatic treatment，oral Misida，intravenous Leigh Ba Velin etc，the treatment group，100 cases of children on the basis of given Saccharomyces Boulardii Powder treatment，two groups of children were treated continuously for 7 days，and continuous observation，clinical effects and adverse reactions of two groups of patients were collected and analyzed.Result：In the treatment group，72 cases were markedly effective，24 cases were effective，the total effective rate was 96.0%，in the control group，47 cases were markedly effective，30 cases were effective，the total effective rate was 78.6%，the treatment group was better than the control group，the difference was statistically significant（P<0.05）.The recovery time of the two groups of patients were statistically and compared，in the treatment group，fever returned to normal time was （3.18±0.46）d，remission time of vomiting was （1.02±0.44）d，relief time of abdominal pain was （1.09±1.08）d，bowel recovery time was （3.14±0.24）d，which were all significantly shorter than （4.25±0.48）d，（1.52±0.63）d，（1.89±1.27）d， （5.97±0.98）d in the control group，the differences were statistically significant（P<0.05）.The incidence rate of adverse reactions in the two groups was compared，there was no statistically significant difference（P>0.05）.Conclusion：Pediatric digestive adverse diarrhea Saccharomyces Boulardii Powder in the treatment effect of the more obvious，which greatly improves the curative effect，also can not only relieve clinical symptoms effectively，and it has high security， it is worth of clinical application.

【Key words】 Saccharomyces Boulardii Powder； Infantile dyspeptic diarrhea； Clinical curative effect observation

First-authors address：Affiliated Nanhua Hospital，University of South China，Hengyang 421002，China

doi：10.14033/j.cnki.cfmr.2016.9.002

小儿腹泻在临床上是一种常见的儿科疾病，最为常见的是消化不良腹泻[1]。具有大便次数增多，性状改变，有不消化物或奶瓣的特点，可伴有发热、腹胀、腹泻、食欲不振、呕吐、腹痛等症状，消化不良性腹泻一般病程较长，恢复较慢，会阻碍小儿的生长发育[2]。因此，对小儿腹泻病的防治十分重要。布拉酵母菌散剂主要用于治疗秋季腹泻，然而对于治疗消化不良性腹泻的研究很少[3]。本研究选取2012年1月-2015年1月于笔……