禤肇泉 谭力雄

[摘要] 目的 探讨卡托普利舌下含服与硝酸甘油静脉滴注治疗高血压急诊患者的临床效果。 方法 选取我院2013年3月～2014年4月收治的高血压急诊患者共105例作为研究对象，采用随机数字表法将其分为观察组、对照组及研究组，各35例。其中对照组给予卡托普利舌下含服治疗，研究组给予硝酸甘油静脉滴注治疗，观察组则给予卡托普利舌下含服联合硝酸甘油静脉滴注治疗，评估三组患者治疗效果，对比三组患者治疗前后收缩压、舒张压以及心率指标变化情况，统计三组患者不良反应发生率。 结果 观察组患者治疗有效率为94.3%，对照组患者治疗有效率为74.3%，研究组患者治疗有效率为85.7%；观察组患者治疗有效率明显高于对照组及研究组（P<0.05）；观察组患者收缩压、舒张压以及心率指标变化优于对照组和研究组（P<0.05）。观察组不良反应发生率17.1%，对照组不良反应发生率14.3%，研究组不良反应发生率17.1%，三组患者治疗过程中不良反应发生率比较，差异无统计学意义（P>0.05）。 结论 卡托普利舌下含服联合硝酸甘油静脉滴注治疗高血压急诊患者有良好的临床效果，患者收缩压、舒张压以及心率指标明显下降，同时不良反应发生率无异常，值得临床推广。

[关键词] 卡托普利；硝酸甘油；高血压急诊；临床指标

[中图分类号] R544.1 [文献标识码] A [文章编号] 1674-4721（2016）02（b）-0149-04

Effect analysis of captopril by sublingual absorption and nitroglycerin by intravenous drip in the treatment of emergency patients due to hypertension

XUAN Zhao-quan TAN Li-xiong

Department of Emergency，Gaoyao People′s Hospital of Zhaoqing City in Guangdong Province，Zhaoqing 526040，China

[Abstract] Objective To explore the clinical effect of captopril by sublingual absorption and nitroglycerin by intravenous drip in the treatment of emergency patients due to hypertension. Methods From March 2013 to April 2014，105 emergency patients due to hypertension admitted into our hospital were selected as research objects.According to a random number table，they were evenly divided into observation group，control group and research group.In the control group， captopril by sublingual taking was provided.In the research group，nitroglycerin by intravenous drip was given，and in the observation group，both of them were adopted.The therapeutic effect among three groups was evaluated.Indexes of systolic pressure （SP），diastolic pressure （DP），heart rate （HR） among three groups were compared，and incidence of adverse reactions among these three groups was calculated. Results The therapeutic effective rate in the observation group，control group，and research group was 94.3%，74.3%，and 85.7%.The effective rate in the observation group was greatly higher than that of control group and research group （P<0.05）.Changes of indexes including SP，DP，and HR were superior than those of control group and research group （P<0.05）.The incidence of adverse reactions in the observation group，control group，and research group was 17.1%，14.3%，and 17.1%，which didn′t display statistical difference （P>0.05）. Conclusion Combination of captopril by sublingual absorption and nitroglycerin by intravenous drip can obtain a good clinical effect in the treatment of emergency patient due to hypertension at advantages of obvious decrease of SP，DP，and HR，and no big difference in incidence of adverse reaction，which is worthy of clinical promotion.

[Key words] Captopril；Nitroglycerin；Emergency due to hypertension；Clinical indicator

当前阶段，临床研究针对心血管疾病等多重因素作用以及心、脑、肾靶器官保护的研究不断深入，高血压诊断标准也在不断调整，高血压作为危害人类健康的基础疾病之一，分析其更加有效的治疗方式仍然是临床研究的重点[1-2]。本次研究将以高血压急诊患者为对象，探讨卡托普利舌下含服与硝酸甘油静脉滴注的治疗效果，报告如下。……