李三群

[摘要] 目的 探讨地屈孕酮与孕三烯酮在卵巢子宫内膜异位症患者行保守手术后的应用效果。 方法 选取我院2014年2～8月收治的75例行保守性手术的卵巢子宫内膜异位症患者，按其入院时间随机分为A组（n=37）与B组（n=38）。A组术后采用地屈孕酮治疗，B组术后采用孕三烯酮治疗。比较两组治疗效果、疼痛评分、术后1年妊娠率及不良反应。 结果 A组缓解率86.5%、改善率2.7%与B组的81.5%、5.3%比较，差异无统计学意义（P>0.05）；A组术后1年妊娠率81.1%高于B组的71.1%（P<0.05）；两组术后3个月、6个月及1年疼痛评分与术前组内比较，差异有统计学意义（P<0.05）；组间比较差异无统计学意义（P>0.05）；A组不良反应发生率10.8%低于B组的26.3%（P<0.05）。 结论 卵巢子宫内膜异位证术后应用地屈孕酮、孕三烯酮进行治疗的效果均相对较好，但前者术后1年妊娠率高，不良反应率低。

[关键词] 卵巢子宫内膜异位症；保守性手术；地屈孕酮；孕三烯酮；效果

[中图分类号] R711.71 [文献标识码] A [文章编号] 1674-4721（2016）02（b）-0146-03

Application effect comparison of dydrogesterone and gestrinone in ovarian endometriosis patients after conservative surgery

LI San-qun

Department of Obstetics and Gynecology，Maoming Petrochemical Hospital of Maoming City in Guangdong Province，Maoming 525000，China

[Abstract] Objective To explore the clinical effect of applying with dydrogesterone or gestrinone respectively for treatment in ovarian endometriosis patients after conservative surgery. Methods From February to August in 2014，75 ovarian endometriosis patients implemented with conservative surgery in our hospital were selected and randomly divided into group A （n=37） and group B （n=38） based on the sequence of admission.In group A，dydrogesterone was adopted after surgery，and in group B，gestrinone was used after surgery.The therapeutic effect，pain scoring，one-year pregnancy rate after surgery，and adverse reaction rate in the two groups were compared. Results The remission rate and improvement rate in group A were 86.5% and 2.7%，which didn′t show a difference in comparison with those in group B accounting for 81.5% and 5.3% respectively （P>0.05）.One-year pregnancy rate after surgery in group A was 81.1%，higher than that of group B，71.1% （P<0.05）.There were significant differences in pain scoring 3，6，and 12 months after surgery compared with those before surgery （P<0.05），but didn′t show statistical difference in inter-groups （P>0.05）.The incidence of adverse reaction in group A was 10.8%，lower than that of group B accounting for 26.3%（P>0.05）. Conclusion After ovarian endometriosis surgery，effect is relatively good if using dydrogesterone or gestrinone for treatment，but the former one has advantages of high one-year pregnancy rate after surgery and low adverse reaction rate.

[Key words] Ovarian endometriosis；Conservative surgery；Dydrogestrone；Gestrinone；Effect

子宫内膜异位症（endometriosis，EMS）属于较为常见的一种妇科疾病，育龄妇女具有较高的发病率[1]，保守性手术是目前治疗EMS的主要方式之一，但术后易复发[2]，所以近年来EMS患者行保守手术后，临床常会采用药物对其进行巩固治疗，且效果较好[3]。我院针对2014年2～8月收治的75例行保守手术卵巢子宫内膜异位症（ovarian endometriosis，OEMS）的患者，分别给予不同的药物进行巩固治疗，均取得了较好的临床效果，现报道如下。

1 资料与方法

1.1 一般资料

选取2014年2～8月我院收治的75例行保守性手术的OEMS患者为研究对象，经病理检查均全部确诊，排除有高血压、其他肿瘤及糖尿病史等合并症患者，患者血尿常规、肝肾功能均无异常，均签署知情同意书接受术后药物巩固治疗。15例OEMS患者按入院时间随机分为A组（n=37）与B组（n=38）。A组年龄（31.5±6.10）岁；美国生殖医学协会MES分期（rAFS）[4]：Ⅰ期1例，Ⅱ期2例，Ⅲ期34例；EMS生育指数（endometriosis fertility index，EFI）[5]为（6.41±1.50）分。B组年龄（32.0±6.23）岁；rAF……