钟飞鹏

[摘要] 目的 比较苯磺酸氨氯地平片与缬沙坦胶囊治疗高血压病的临床效果。 方法 选取2009年10月～2012年10月在本院就诊治疗的120例高血压病患者作为研究对象，按照治疗方法的不同分为治疗组（62例）和对照组（58例）。治疗组给予苯磺酸氨氯地平片，对照组给予缬沙坦胶囊，比较两组治疗前后的舒张压和收缩压水平，评价其疗效与不良反应。 结果 治疗组的总有效率为82.3%，显著高于对照组的74.1%，差异有统计学意义（P<0.05）。两组治疗后的舒张压和收缩压显著低于治疗前，差异有统计学意义（P<0.05）。治疗组治疗后的舒张压和收缩压显著低于对照组治疗后，差异有统计学意义（P<0.05）。治疗组的不良反应主要有头痛1例和水肿3例，对照组的不良反应主要有干咳5例、头晕和疲乏各1例。 结论 苯磺酸氨氯地平片治疗高血压病效果优于缬沙坦胶囊。

[关键词] 高血压病；氨氯地平；缬沙坦

[中图分类号] R544.1 [文献标识码] A [文章编号] 1674-4721（2016）02（b）-0131-03

Clinical effect comparison of amlodipine and valsartan in the treatment of hypertension disease

ZHONG Fei-peng

Department of Emergency，Enping Branch of Wuyi Hospital of Traditional Chinese Medicine of Enping City in Guangdong Province，Enping 529400，China

[Abstract] Objective To compare the clinical effect of amlodipine besylate tablet and valsartan capsule in the treatment of hypertension disease. Methods 120 cases of hypertension from October 2009 to October 2012 in our hospital were selected and divided into the treatment group （n=62） and the control group （n=58） according to different treatment methods.The treatment group was given amlodipine besylate tablet，the control group was given valsartan capsule.The level of diastolic blood pressure and systolic blood pressure before and after treatment was compared in the two groups，and the effect and adverse reaction was evaluated. Results The total effective rate in the treatment group was 82.3%，which was higher than 74.1% in the control group，with significant difference （P<0.05）.The diastolic blood pressure and the systolic blood pressure in the two groups after treatment was lower than that before treatment，with significant difference （P<0.05）.The diastolic blood pressure and the systolic blood pressure in the treatment group after treatment was lower than that in the control group after treatment，with significant difference （P<0.05）.The main adverse effects of the treatment group were headache （n=1） and edema （n=3），which were dry cough （n=5），dizzy （n=1） and tire （n=1） of the control group. Conclusion The effect of amlodipine besylate tablet in the treatment of hypertension disease is better than valsartan capsule.

[Key words] Hypertension disease；Amlodipine；Valsartan

高血压（hypertension）是一种以体循环动脉压增高为主要特点的临床综合征，可分为原发性高血压（高血压病）和继发性高血压（症状性高血压）两大类，其中原发性高血压占高血压的95%以上。继发性高血压是指血压升高为某些疾病的临床表现，占高血压的5%以下。研究显示，血压水平与心脑血管疾病发病和死亡风险之间存在着极为密切的关系。目前，我国高血压患病率约为20%，占全球高血压患者总数的1/5。治疗高血压病的关键是将患者的血压维持在一个合理的水平，从而减少心脑血管疾病的发生。治疗高血压病的常用药物有钙拮抗剂（CCB）、血管紧张素转换酶抑制剂（ACEI）、血管紧张素Ⅱ受体拮抗剂（ARB）、利尿剂、β受体阻滞剂、α受体阻滞剂等。苯磺酸氨氯地平片是CCB类药物，缬沙坦是ARB类药物，两者在治疗高血压病中的应用较为广泛，但是目前尚未见到关于苯磺酸氨氯地平片和缬沙坦胶囊临床疗效和安全性比较的文献报道。……