杨泰源 罗玲

[摘要] 目的 研究奥曲肽和奥美拉唑钠联合治疗肝硬化合并上消化道出血的效果及患者出血和住院时间的影响。 方法 选取我院于2013年6月～2015年6月收治的74例肝硬化合并上消化道出血患者，将其随机分为观察组与对照组，各37例。对照组给予奥美拉唑钠进行治疗，观察组给予奥曲肽联合奥美拉唑进行治疗，观察两组患者的治疗效果、出血及住院时间进行对比分析。 结果 观察组的治疗总有效率为97.29%（36/37），对照组的治疗总有效率为75.68%（28/37），两组结果比较，差异有统计学意义（P<0.05）；观察组出血及住院时间均明显短于对照组，差异有统计学意义（P<0.05）；观察组患者的不良反应发生率显著低于对照组，差异有统计学意义（P<0.05）。结论 对肝硬化合并上消化道出血患者采用奥曲肽联合奥美拉唑钠进行治疗，其效果显著，能够明显缩短患者的出血及住院时间，值得临床推广与应用。

[关键词] 奥曲肽；奥美拉唑钠；肝硬化；上消化道出血

[中图分类号] R657.3+1 [文献标识码] A [文章编号] 1674-4721（2016）02（b）-0119-03

Octreotide and omeprazole sodium combined treatment of gastrointestinal bleeding effect of cirrhosis of the liver and the effect on bleeding and hospitalization time

YANG Tai-yuan1 LUO Ling2

Department of Pharmacy，the Center Hospital of Longgang in Shenzhen City，Shenzhen 518116

[Abstract] Objective To study octreotide and omeprazole sodium combined treatment effect of cirrhotic patients with upper digestive tract hemorrhage and the effect of patients with bleeding and hospitalization time. Methods 74 patients with cirrhosis complicated with upper digestive tract hemorrhage in our hospital from June 2015 to June 2013 were selected，They were randomly divided into observation group and control group，each of 37 cases.The control group was treated with omeprazole sodium，the observation group was given octreotide combined omeprazole treatment，the treatment effect，bleeding and hospitalization time of the two groups were compared and analyzed. Results The total effective rate in the observation group was 97.29% （36/37），and the control group was 75.68% （28/37），the difference of the two groups was statistically significant （P<0.05）；The bleeding and hospitalization time of the observation group were significantly shorter than that of control group，and the difference between the two groups was statistically significant（P<0.05）；The incidence of adverse reactions in the observation group was significantly lower than that of control group，and the difference of the two groups was statistically significant （P<0.05）. Conclusion For cirrhosis combined with upper gastrointestinal hemorrhage were treated with octreotide and omeprazole sodium，the effect is obvious，can significantly shorten the patient's bleeding and hospitalization time，worthy of clinical popularization and application.

[Key words] Octreotide；Omeprazole sodium；Liver cirrhosis；Upper gastrointestinal hemorrhage

肝硬化是一种临床常见的慢性肝病，该病的发病机制为由于多种致病因素反复或者长期作用下所导致的弥漫性肝脏损伤，进而引起门脉高压及肝功能障碍等并发症，其中上消化道出血是其常见的一种并发症，通常会令患者在很短的时间内发生急性周围循环衰竭，给患者的生命安全带来了严重的影响[1-2]。奥美拉唑是临床上较为常用的用于治疗肝硬化合并有上消化道出血的一种药物，该药物能够选择性降低胃壁细胞的ATP酶的活性，从而达到对胃酸分泌的阻断作用，保持血小板凝集以及胃蛋白酶活性的清楚具有极其重要的意义，但在临床应用过程中，单独使用的疗效不是很明显。本研究在2013年6月～2015年6月对我院收治的74例肝硬化合并上消化道出血采用奥曲肽联合奥美拉唑钠进行治疗，研究其治疗效果及对患者出血及住院时间的影响，现报道如下。……