庄金田

【摘要】 目的 观察甘草酸二铵肠溶胶囊联合水飞蓟宾胶囊治疗酒精性肝损伤的疗效。方法 80例酒精性肝损伤患者， 随机分为治疗组和对照组， 各40例。治疗组应用甘草酸二铵肠溶胶囊联合水飞蓟宾胶囊治疗， 对照组应用维生素C片联合水飞蓟宾胶囊治疗。观察比较两组治疗效果。结果 治疗后， 两组丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、谷氨酰转肽酶（GGT）水平均较治疗前降低， 差异均有统计学意义（P<0.05）；且治疗组低于对照组， 差异均有统计学意义（P<0.05）。治疗组总有效率92.5%优于对照组的80.0%， 差异有统计学意义（P<0.05）。结论 甘草酸二铵肠溶胶囊联合水飞蓟宾胶囊治疗酒精性肝损伤疗效确切， 值得临床推广应用。

【关键词】 酒精性肝损伤；甘草酸二铵肠溶胶囊；水飞蓟宾胶囊；疗效观察

DOI：10.14163/j.cnki.11-5547/r.2016.04.004

Observation of curative effect by diammonium glycyrrhizinate enteric-coated capsules combined with silibinin capsules in the treatment of alcoholic liver injury ZHUANG Jin-tian. Department of Infection， Lanling County Peoples Hospital， Linyi 277799， China

【Abstract】 Objective To observe curative effect by diammonium glycyrrhizinate enteric-coated capsules combined with silibinin capsules in the treatment of alcoholic liver injury. Methods A total of 80 patients with alcoholic liver injury were randomly divided into treatment group and control group， with 40 cases in each group. The treatment group received diammonium glycyrrhizinate enteric-coated capsules combined with silibinin capsules for treatment， and the control group received vitamin C tablets combined with silibinin capsules for treatment. Curative effects of the two groups were observed. Results After treatment， both groups had decreased levels of alanine aminotransferase （ALT）， aspartate aminotransferase （AST） and gamma-glutamyl transpeptidase （GGT）， and their differences all had statistical significance （P<0.05）. Those in the treatment group were all lower than those in the control group， and the differences all had statistical significance （P<0.05）. The treatment group had better total effective rate as 92.5% than 80.0% of the control group， and the difference had statistical significance （P<0.05）. Conclusion Combination of diammonium glycyrrhizinate enteric-coated capsules and silibinin capsules provides precise effect in treating alcoholic liver injury， and it is worth clinical promotion and application.

【Key words】 Alcoholic liver injury； Diammonium glycyrrhizinate enteric-coated capsules； Silibinin capsules； Observation of curative effect

酒精性肝损伤是由于长期大量饮酒所致肝脏病变， 包括酒精性脂肪肝、酒精性肝炎、酒精性肝硬化等。我国是一个酒消耗大国， 随着嗜酒人群比例的上升， 酒精性肝损伤的发病比例也呈上升趋势。最常见的就是酒精性脂肪肝。对于酒精性肝损伤目前尚无特效治疗药物[1]。本院对2011年7月～ 2014年6月门诊诊断40例酒精性肝损伤患者， 采用口服甘草酸二铵肠溶胶囊联合水飞蓟宾胶囊治疗， 收到较满意效果， 现报告如下。

1 资料与方法

1. 1 一般资料 选取2011年7月～2014年6月本院门诊诊断的80例酒精性肝损伤患者， 纳入标准：①有长期大量饮酒史；②无明显症状或有轻度乏力、纳差、右上腹不适等；③实验室检查：ALT、AST、GGT均不同程度升高；④彩超检查：均符合肝回声改变声像；⑤排除病毒感染、药物及非酒精引起的肝损伤；⑥无药物应用的禁忌证。按照就诊卡号随机分为治疗组及对照组， 各40例。治疗组男33例， 女7例， 年龄26～61岁， 平均年龄45岁， 病程0～5年， 平均病程1.6年。……