张雪晶

他汀类药物治疗扩张性心肌病的临床疗效分析

张雪晶

目的 分析他汀类药物治疗扩张性心肌病的临床疗效。方法 抽取来我院治疗扩张性心肌病的76例患者，随机分为对照组与观察组，各38例。对照组采取常规药物治疗，观察组则在对照组基础上给予阿托伐他汀治疗，两组均治疗3个月，对比两组临床疗效及不良反应发生情况。结果 治疗后，观察组总有效率为92.1%（35/38），对照组为73.6%（28/38），观察组高于对照组，差异具有统计学意义（P＜0.05）；不良反应发生率组间比较，差异无统计学意义（P＞0.05）。结论 应用他汀类药物治疗扩张性心肌病可显著提高治疗效果，不良反应较低，安全有效。

扩张性心肌病；他汀类药物；疗效

【Abstract】

Objective To analyze the clinical effect of statins in the treatment of dilated cardiomyopathy. Methods Extraction of 76 cases of patients with dilated cardiomyopathy in our hospital， they were randomly divided into the control group and the observation group， each group had 38 cases. Control group was treated with routine drug therapy， the observation group was given atorvastatin treatment on the basis of the control group， two groups were treated for 3 months， the clinical efficacy and adverse reactions of the two groups were compared. Results After treatment， the total effective rate of the observation group was 92.1%（35/38）， the control group was 73.6%（28/38）， the observation group was higher than the control group，the difference was statistically significant（P＜0.05）； Adverse incidence rate was compared between two groups，the difference was not statistically significant（P＞0.05）. Conclusion Application of statins in the treatment of dilated cardiomyopathy can significantly improve the treatment effect， adverse reaction is lower， safe and effective.

【Key words】Dilated cardiomyopathy， Statins， Curative effect

扩张性心肌病特点为患者右心室或左心室明显扩大，且常伴有不同程度心室收缩功能减退、心肌肥厚［1-2］。目前，扩张性心肌病的发病率逐年升高，且致死率较高，严重威胁患者生命健康［3］。研究报道［4］，他汀类药物可有效调节血脂，减少胆固醇合成，并改善患者心功能，缓解其心衰进程。本研究为进一步分析他汀类药物治疗扩张性心肌病的临床疗效，抽取来我院治疗的扩张性心肌病患者76例，分组分析，具体报道如下。

1　资料和方法

1.1 一般资料

抽取2012年4月～2016年2月来我院治疗扩张性心肌病的76例患者，随机分为对照组与观察组，各38例。对照组男18例，女20例，平均年龄（47.4±9.6）岁，心功能分级：Ⅱ级24例，Ⅲ级14例；观察组男17例，女21例，平均年龄（46.9±10.2）岁，心功能分级：Ⅱ级25例，Ⅲ级13例。统计显示两组心功能分级、性别、年龄等资料比较，差异无统计学意义（P＞0.05）。……