冷立娟　冷　钦

作者单位：潍坊医学院附属胶州中心医院　心内科　266300

【摘要】　目的　观察瑞舒伐他汀联合左卡尼汀治疗不稳定性心绞痛的疗效。方法　80例冠心病不稳定性心绞痛患者随机分为观察组和对照组各40例。两组患者给予应用硝酸酯类药物、β-受体阻滞剂、抗血小板类药物等常规对症治疗，对照组在常规处理基础上给予口服瑞舒伐他汀10mg(1次/日)；观察组患者在对照组处理基础上，给予左卡尼汀3.0g静滴(1次/日)，疗程10天。结果　观察组心绞痛症状改善总有效率为95.0%，明显高于对照组的77.5%，组间比较差异具有显著性(P<0.05)；观察组心电图改善总有效率达87.5%高于对照组的70%，差异具有显著性(P<0.05)。结论　瑞舒伐他汀联合左卡尼汀治疗冠心病不稳定性心绞痛疗效显著。

【关键词】　瑞舒伐他汀　不稳定性心绞痛　左卡尼汀

瑞舒伐他汀联合左卡尼汀治疗不稳定性心绞痛疗效观察

冷立娟冷钦

作者单位：潍坊医学院附属胶州中心医院心内科266300

【摘要】目的观察瑞舒伐他汀联合左卡尼汀治疗不稳定性心绞痛的疗效。方法80例冠心病不稳定性心绞痛患者随机分为观察组和对照组各40例。两组患者给予应用硝酸酯类药物、β-受体阻滞剂、抗血小板类药物等常规对症治疗，对照组在常规处理基础上给予口服瑞舒伐他汀10mg(1次/日)；观察组患者在对照组处理基础上，给予左卡尼汀3.0g静滴(1次/日)，疗程10天。结果观察组心绞痛症状改善总有效率为95.0%，明显高于对照组的77.5%，组间比较差异具有显著性(P<0.05)；观察组心电图改善总有效率达87.5%高于对照组的70%，差异具有显著性(P<0.05)。结论瑞舒伐他汀联合左卡尼汀治疗冠心病不稳定性心绞痛疗效显著。

【关键词】瑞舒伐他汀不稳定性心绞痛左卡尼汀

作者简介：冷立娟，硕士研究生，主治医师，研究方向：冠心病。

doi:10.3969/j.issn.1672-4860.2015.06.025

【Abstract】ObjectivesTo observe the effect of rosuvastatin combined with L-carnitine in treatment of unstable angina. Methods80 patients with unstable angina were divided randomly into the observed group (n=40) and the controlled group (n=40). All patients in the both groups were treated with nitrates, β-blockers, antiplatelet, other conventional symptomatic treatments, and rosuvastatin 10mg once daily for ten days；while intravenous L-carnitine 3.0g once daily were added in the observed group for ten days. ResultsThe total effective rate of improvement of angina pectoris symptom was significantly higher in the observed group compared in the control group (95%vs. 77.5%; P<0.05). Also, the total effective rate of improvement of ECG was significantly higher in the observed group compared in the control group (87.5%vs. 70%; P<0.05). ConclusionsRosuvastatin combined with L-carnitine in treatment of unstable angina has significant effect.

收稿日期：2015-10-17

Effects of Rosuvastatin combined with L-Carnitine in Treatment of unstable Angina(LENGLijuan,LENGQin.JiaozhoucentralhospitalaffiliatedtoWeifangmedicaluniversity,Jiaozhou266300,China.)

【Key words】Rosuvastatin, unstable angina, L-carnitine

不稳定性心绞痛是冠状动脉硬化性心脏病(简称冠心病)中常见的一种类型，是严重、具有潜在危险的疾病，此类患者临床病情不稳定，易发生急性心肌梗死和心源性猝死，治疗目的是缓解心肌缺血，解除心绞痛症状，预防心肌梗死和死亡。……