慢性乙肝合并肝硬化患者血清谷丙转氨酶、乙肝表面抗原水平与肝功能的相关性*

洪江**刘娟

（广东省东莞市康复医院检验科 东莞 523119）

摘 要目的：探讨慢性乙肝合并肝硬化患者血清谷丙转氨酶（ALT）、乙肝表面抗原（HBsAg）水平与肝功能的相关性。方法：选取我院慢性乙型肝炎合并肝硬化患者215例，根据肝功能Child-Pugh分级将患者分为3组，其中A组（Child-Pugh A级）75例，B组（Child-Pugh B级）73例，C组（Child-Pugh C级）67例；全部患者均检测ALT、HBsAg水平。结果：A组ALT、HBsAg水平均明显低于B、C组，B组ALT、HBsAg水平均明显低于C组；且A组ALT异常率明显低于B、C组，B组ALT异常率明显低于C组。组间比较差异均具有显著性。结论：慢性乙肝合并肝硬化患者血清ALT、HBsAg与肝功能显著相关，ALT、HBsAg水平越低，肝功能受损程度越低。

关键词慢性乙肝 血清谷丙转氨酶 乙肝表面抗原 肝功能

*基金项目：广东省东莞市科技计划医疗卫生类科研一般项目（项目编号：20131051010134）

The correlation between the levels of serum alanine aminotransferase and hepatitis B surface antigen and the liver function in the patients with chronic hepatitis B and liver cirrhosis*

HONG Jiang**

(Clinical Laboratory, Rehabilitation Hospital of Dongguan City, Guangdong Province, Dongguan 523119, China)

ABSTRACTObjective: To investigate the correlation between the levels of serum alanine aminotransferase (ALT) and hepatitis B surface antigen(HBsAg) and the liver function in the patients with chronic hepatitis B and liver cirrhosis. Methods: Two hundred and fifteen cases of the patients in our hospital were selected and divided into three groups based on their Child-Pugh grade of liver function: group A (Child-Pugh grade A, 75 cases), group B (Child-Pugh grade B, 73 cases) and group C (Child-Pugh grade C, 67 cases). ALT and HBsAg level of all patients were detected. Results: The ALT and HBsAg level of group A were significantly lower than those of group B and C and the ALT and HBsAg level of group B were significantly lower than those of group C. So was the abnormal rate of ALT. All the differences were statistically significant. Conclusion: The serum levels of ALT and HBsAg in patients with chronic hepatitis B and liver cirrhosis have significant correlation with liver function. The degree of liver dysfunction is lower when the levels of ALT and HBsAg are also lower.

KEY WORDSchronic hepatitis B; serum ALT; HBsAg; liver function

慢性乙型肝炎（乙肝）是由乙型肝炎病毒导致的传染性疾病，血清乙肝表面抗原（hepatitis B virus surface antigen，HBsAg）阳性提示乙肝病毒感染，乙肝表面抗原转阴显著降低慢性乙型肝炎并发肝硬化和肝癌发生风险[1]。血清谷丙转氨酶（alanine aminotransferase，ALT）水平有助于反映肝功能代谢程度[2]。因此，慢性乙肝合并肝硬化患者ALT、HBsAg水平与肝功能的关系紧密。

1 资料与方法

1.1 临床资料

选取我院2014年1月-2014年12月期间消化内科慢性乙型肝炎合并肝硬化患者215例。纳入标准：全部患者入院前均未接受抗病毒治疗，入院后检测ALT、HBsAg水平，HBsAg阳性大于6个月。排除标准：合并丙型病毒性肝炎、丁型病毒性肝炎、戊型病毒性肝炎、药物性肝功能受损、酒精性肝脏疾病和自身免疫性疾病等。……