罗敏席晨希(.上海市虹口区欧阳社区卫生服务中心口腔科 上海；0008;.上海市宝山区大场医院口腔科 上海 00436)

盐酸米诺环素软膏联合口腔托盘治疗系统治疗牙周炎的临床疗效

罗敏1席晨希2
(1.上海市虹口区欧阳社区卫生服务中心口腔科 上海；200081;2.上海市宝山区大场医院口腔科 上海 200436)

摘 要目的：研究盐酸米诺环素软膏联合口腔托盘治疗系统治疗牙周炎的临床疗效。方法：选取牙周炎患者57例共124牙，随机分为实验组和对照组，实验组采用口腔托盘给药系统给予盐酸米诺环素软膏，对照组采用传统的方法给药，治疗前和治疗后第2、4周比较两组患者牙周探诊深度、牙龈指数和探诊出血情况。结果：试验组和对照组治疗后第2、 4周以上3 项牙周检测指标均低于治疗前，试验组患牙的GI、PD 和BOP在治疗后第2、4周均低于对照组（P< 0.05）。结论：在牙周基础治疗的基础上，采用口腔托盘给药系统给予盐酸米诺环素软膏治疗牙周炎能显著改善患者牙周的探诊深度，牙龈指数和探诊出血状况，且药效持续更为长久，效果更为明显。

关键词派丽奥 牙周炎 托盘治疗系统

The clinical effects of periocline with the dental drug delivery system for curing the periodontitis

LUO Min1, XI Chenxi2
(1.Department of Stomatology, Ouyang Community Health Service Center of Hongkou District, Shanghai 20008， China; 2.Department of Stomatology, Dachang hospital of Baoshan District, Shanghai 200436, China)

ABSTRACTObjective: To investigate the clinical effects of periocline with the dental drug delivery system for curing the periodontitis. Methods: Fifty-seven patients with total 124 periodontitis teeth were selected and randomly divided into an experimental group and a control group, in which minocycline hydrochloride ointment was administered via the dental drug delivery system in the experimental group while by a traditional method in the control group. Probing depth (PD) gingival index (GI) and bleeding on probing (BOP) were detected before treatment and 2，4 weeks after treatment. Results: Three periodontal detection indexes above mentioned were lower after treatment than before in both groups and in the experimental group than in the control group (P＜0.05). Conclusion: On the basis of periodontal therapy，three periodontal detection indexes are obviously improved when minocycline hydrochloride ointment is administered via the dental drug delivery system, and the efficacy can be sustained much longer and the effect is more obvious.

KEY WORDSperiocline; periodontitis; the dental drug delivery system

牙周炎（periodontal disease）是人类最古老、最普遍的疾病之一，也是目前最常见的口腔疾病之一[1]。牙周炎若不及时治疗会导致牙齿松动最后拔除，影响患者的咀嚼功能和美观。近几十年来，诸多流行病学研究表明，牙周炎与全身系统性疾病具有相关性[2]，如心血管疾病、代谢综合征、糖尿病、不良妊娠结局、呼吸系统疾病、类风湿性关节炎、肾脏疾病、癌症、炎症性肠病及阿尔茨海默病等。牙周炎与这些全身系统性疾病具有相互促进的关系，牙周炎会加重全身系统性疾病的病程，增加治疗的难度，全身系统性疾病会促进牙周炎的发展，故牙周炎的治疗势在必行。……