茵栀黄颗粒联合双歧杆菌三联活菌胶囊治疗新生儿高胆红素血症疗效观察

2016-01-21朱红文张理斐张慧娟郑州市第三人民医院儿科郑州450009

上海医药 2015年5期

朱红文张理斐张慧娟（郑州市第三人民医院儿科郑州 450009）

朱红文张理斐张慧娟
（郑州市第三人民医院儿科郑州 450009）

摘要目的：观察茵栀黄颗粒联合双歧杆菌三联活菌胶囊治疗新生儿高胆红素血症的疗效。方法：将高胆红素血症患儿依家长意愿分为两组，观察组予茵栀黄颗粒联合双歧杆菌三联活菌胶囊口服，对照组予清肝利胆口服液口服，连服5 d，观察两组患儿经皮胆红素的变化。结果：观察组与对照组治疗5 d后，黄疸均较前减轻，但观察组疗效更显著，不良反应较对照组少。结论：茵栀黄颗粒联合双歧杆菌三联活菌胶囊治疗新生儿高胆红素血症疗效确切，不良反应较少。

关键词茵栀黄颗粒新生儿高胆红素血症双歧杆菌三联活菌胶囊

Observation of the efficacy of yinzhihuang particles combined with bifid triple viable capsule in the treatment of neonatal with hyperbilirubinemia

ZHU Hongwen, ZHANG Lifei, ZHANG Huijuan
(Department of pediatrics, The Third People’S Hospital of Zhengzhou City, Zhengzhou 450009, China)

ABSTRACTObjective: To investigate the clinical efficacy of yinzhihuang particles combined with bifid triple viable capsule in the treatment of neonatal with hyperbilirubinemia. Methods: Newborn infants with hyperbilirubinemia were divided into an observation group and a control group based on the request of parents. Yinzhihuang particles combined with bifid triple viable capsule were given in the observation group while only Qinggan-Lidan decoction in the control group for 5 days. The efficacy and the changes of transcutaneous bilirubin measurement were observed and compared between the two groups. Results: The jaundice was all regressed in the two groups but the efficacy was more significant in the observation group than in the control group (P<0.05), and the incidence of adverse reactions was less in the observation group than in the control group. Conclusion: The efficacy of Yinzhihuang particles combined with bifid triple viable capsule in the treatment of neonatal with hyperbilirubinemia is more effective with less adverse reactions.

KEY WORDSyinzhihuang; neonatal; hyperbilirubinemia; bifid triple

高胆红素血症是新生儿期常见症状，其严重并发症为胆红素脑病，可影响小儿的神经、精神、智力的发育，目前蓝光照射仍是治疗新生儿高未结合胆红素血症的主要方法之一。由于光疗时间长，易出现脱水、发热、腹泻、皮疹等不良反应，且治疗费用高，母婴分离，许多家长不能接受。我们用茵栀黄颗粒联合双歧杆菌三联活菌胶囊对一定病例门诊治疗，取得较好疗效，报道如下。