刘琼（江西省景德镇市第三人民医院妇产科 景德镇 333000）

克罗氯米芬与来曲唑治疗多囊卵巢不孕症患者的对比研究

刘琼
（江西省景德镇市第三人民医院妇产科 景德镇 333000）

摘 要目的：探讨克罗氯米芬与来曲唑治疗多囊卵巢不孕症患者的疗效。方法：选取我院多囊卵巢不孕症患者78例，随机将其分为两组，克罗氯米芬组（37例）采用克罗氯米芬片治疗，来曲唑组（41例）采用来曲唑治疗，比较两组患者治疗效果。结果：来曲唑组促排卵成功率和妊娠率均明显高于克罗氯米芬组（P<0.05），治疗后，来曲唑组患者优势卵泡数量和成熟卵泡数量均明显多于克罗氯米芬组（P<0.05）。人绒毛膜促性腺激素注射日，来曲唑组宫颈黏液评分值和子宫内膜厚度均明显高于克罗氯米芬组，血清E2值明显低于克罗氯米芬组（P<0.05）。随访6个月发现，克罗氯米芬组出现黄素化未破裂卵泡综合征8例，来曲唑组出现1例，两者比较差异具有统计学意义（P<0.05）。两组经促排卵治疗后均接受黄体支持治疗，全部患者无流产现象发生。结论：来曲唑治疗多囊卵巢不孕症患者疗效更显著，提高排卵率和妊娠率。

关键词克罗氯米芬 来曲唑 多囊卵巢不孕症

Comparative study on the effect of crow clomiphene and letrozole in the treatment of polycystic ovarian infertility

LIU Qiong
(Department of Obstetrics and Gynecology in the Third People’s Hospital of Jingdezhen, Jingdezhen 333000, China)

ABSTRACTObjective: To compare the effect of crow clomiphene and letrozole in the treatment of patients with polycystic ovarian infertility. Methods: Seventy-eight cases of patients with polycystic ovarian infertility in our hospital were randomly divided into a crow clomiphene group (37 cases) and a letrozole group (41 cases), which were treated with crow clomiphene citrate tablets or letrozole, respectively and their efficacy was compared. Results: Ovulation and pregnancy success rates were obviously higher in the letrozole group than in the crow clomiphene group (P<0.05). After treatment, the number of dominant follicles and mature follicles was significantly more in the letrozole group than in the crow clomiphene group (P<0.05), cervical mucus score and endometrial thickness were significantly higher in the letrozole group than in the crow clomiphene group on the day for human chorionic gonadotropin injection while serum E2value was significantly lower in the letrozole group than in the crow clomiphene group (P<0.05). Eight cases of luteinized unruptured follicle syndrome, which was a main adverse reaction, occurred in the crow clomiphene group while only one case in the letrozole group during 6 months of follow-up and comparison between two groups had statistical significance (P<0.05). Luteal support therapy was received in two groups after ovulation induction therapy and none of abortion phenomenon occurred. Conclusion: The curative effect of letrozole in the treatment of polycystic ovarian infertility is much more remarkable and can improve the ovulation and pregnancy rates.

KEY WORDScrow clomiphene; letrozole; polycystic ovarian infertility

多囊卵巢不孕症是指多囊性卵巢综合征（polycystic ovary syndrome，PCOS）继发不孕症的内分泌失调性疾病，主要临床表现为多囊卵巢病变、高雄激素水平、高雄激素血症导致长期少排卵甚至不排卵的病理改变[1]。文献报道显示，多囊卵巢不孕症是育龄妇女的主要不孕原因之一[2]。临床常规应用药物治疗，本研究探讨克罗氯米

芬与来曲唑治疗多囊卵巢不孕症患者的临床疗效，现报道如下。

1 资料与方法

1.1 临床资料

选取2013年1月-2014年1月期间我院妇科住院部收治的多囊卵巢不孕症患者78例。纳入标准：全部患者符合PCOS诊断标准(稀发排卵或无排卵、高雄激素血症和卵巢直径2~9 mm、卵泡≥10个，以上三项中符合两项者)，且符合不孕症诊断标准（配偶生殖功能和性生活正常、未采取任何避孕措施的基础上夫妻生活2年未成功受孕），未给予任何促排卵治疗措施。排除标准：子宫内膜功能异常或非多囊卵巢病变导致的不孕症状，男方不孕症，女方精神性疾病患者。……