林贻照

[摘要] 目的 探讨慢性阻塞性肺疾病合并呼吸衰竭患者接受无创呼吸机治疗的临床效果。方法 研究对象随机选取该院2012年2月—2015年3月慢性阻塞性肺疾病合并呼吸衰竭患者100例，按照双盲法将100例患者随机分为对照组与观察组，每组50例。对照组50例患者接受常规治疗，观察组患者在对照组的基础上联合无创正压通气治疗，观察两组患者治疗前后血气分析变化。结果 治疗前，对照组患者pH值为（7.21±0.06），观察组患者pH值为（7.22±0.09），对照组患者PaCO2值为（84.74±22.06）mmHg，PaO2值为（53.85±5.35）mmHg，观察组患者PaCO2值为（81.54±23.06）mmHg，PaO2值为（51.15±5.27）mmHg，治疗后，对照组患者pH值为（7.31±0.04），观察组患者pH值为（7.39±0.06），对照组患者PaCO2值为（65.25±15.32）mmHg，PaO2值为（61.85±7.65） mmHg，观察组患者PaCO2值为（45.36±9.18）mmHg，PaO2值为（80.69±9.63）mmHg。治疗前两组患者血气分析对比差异无统计学意义（P>0.05），治疗后两组患者血气分析差异有统计学意义（P<0.05）。结论 无创呼吸机正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭疗效确切，值得进行推广应用。

[关键词] 慢性阻塞性肺疾病合并呼吸衰竭；无创呼吸机

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2015）12（a）-0046-02

[Abstract] Objective To investigate the clinical effect of noninvasive ventilator in the treatment of chronic obstructive pulmonary disease with respiratory failure. Methods 100 patients with chronic obstructive pulmonary disease complicated with respiratory failure admitted in our hospital from February 2012 to March 2015 were selected and randomly divided into control group and observation group with 50 cases in each in accordance with the double-blind method. Both groups were given the conventional treatment， in addition， the observation group were treated with noninvasive positive pressure ventilation. And the result of the blood gas analysis of the two groups was observed before and after treatment. Results Before treatment， the value of pH， PaCO2 and PaO2 of the control group was （7.21±0.06）， （84.74±22.06）mmHg， （53.85±5.35）mmHg， respectively， and that of the observation group was （7.22±0.09）， （81.54±23.06）mmHg， （51.15±5.27）mmHg， respectively， which showed there was no statistically significant difference in the result of blood gas analysis between the two groups before treatment（P>0.05）. After treatment， the value of pH， PaCO2 and PaO2 of the control group was （7.31±0.04）， （65.25±15.32）mmHg， （61.85±7.65）mmHg， respectively， and that of the observation group was （7.39±0.06）， （45.36±9.18）mmHg， （80.69±9.63）mmHg， respectively， which indicated that the difference in the result of blood gas analysis between the two groups after treatment was statistically significant（P<0.05）. Conclusion Noninvasive positive pressure ventilation has exact effect on chronic obstructive pulmonary disease with respiratory failure， which is worthy of promotion and application.

[Key words] Chronic obstructive pulmonary disease with respiratory failure； Noninvasive ventilator

据临床研究结果[1-2]显示，我国慢性阻塞性肺疾病患者中，约有15%～35%的患者需要接受机械通气治疗。慢性阻塞性肺疾病使患者的呼吸阻力大增，使患者呼吸困难，当合并呼吸衰竭后，便会加重患者病情，对患者生命构成威胁。针对这一现状，在常规治疗的基础上给予患者无创呼吸机治疗的重要性日益凸显[3]。为探讨慢性阻塞性肺疾病合并呼吸衰竭患者接受无创呼吸机治疗的临床效果。随机选取该院2012年2月—2015年3月慢性阻塞性肺疾病合并呼吸衰竭患者接受无创呼吸机治疗，取得了令人满意的疗效，现报道如下。

1 资料与方法