坎地沙坦联合曲美他嗪治疗原发性高血压左室肥厚的临床观察

王春梅，文军，丁润会，刘叶，嵇诚，郭景华，袁志勇

(秦皇岛市海港医院，河北 秦皇岛 066000)

摘要：目的观察坎地沙坦联合曲美他嗪治疗原发性高血压左室肥厚的疗效。方法原发性高血压患者115例，随机分为两组，A组采用坎地沙坦口服，B组采用坎地沙坦联合口服曲美他嗪，比较两组降压效果、超声心动图指标的改变。结果两组患者血压均较治疗前明显下降(P<0.05)，但两组间降压效果比较无统计学差异(P>0.05)；两组LVEDd、LVPWT、IVST、LVMI、LVEF及E/A均显著改善，且B组均优于A组(P<0.05)。结论采用坎地沙坦联合曲美他嗪较单纯采用坎地沙坦治疗可更明显逆转原发性高血压左室肥厚、改善心功能。

关键词：坎地沙坦；曲美他嗪；高血压；左室肥厚

作者简介：王春梅，副主任医师，研究方向：心血管内科，E-mail：wcm1971228@aliyun.com

中图分类号：R969.4文献标识码：A

Clinical observation of Candesartan combined with Trimetazidine on treating ventriculus

sinister hypertrophy of essential hypertension

WANGChun-mei,WENJun,DINGRun-hui,LIUYe,JICheng,GUOJing-hua,YUANZhi-yong

(QinhuangdaoHaigangHospital,Qinhuangdao066000,China)

Abstract：ObjectiveTo observe the curative effect of Candesartan combined with Trimetazidine on treating ventriculus sinister hypertrophy of essential hypertension.Methods115 cases of essential hypertension patients were divided into two groups randomly.A group was treated by Candesartan orally and B group was treated by Candesartan combined with Trimetazidine.The antihypertensive effect and changes of echocardiogram index of two groups were compared.ResultsCompared with pretherapy,the blood pressures of patients in two groups were obviously reduced(P<0.05),but the antihypertensive effects had no statistics difference(P>0.05).LVEDd,LVPWT,IVST,LVMI,LVEF and E/A in two groups were obviously improved and B group was all better than A group(P<0.05).ConclusionCompared with treating only with Candesartan,Candesartan combined with Trimetazidine can obviously reverse the ventriculus sinister hypertrophy of essential hypertension and improve heart function.

Key words:Candesartan;Trimetazidine;Hypertension;Ventriculus sinister hypertrophy

高血压为心血管疾病的常见病、多发病，高血压可导致心、肾、脑等靶器官的损害，因此临床不仅要重视降低血压，同时应注重保护靶器官功能，减少并发症，改善患者预后。本研究采用坎地沙坦联合曲美他嗪治疗原发性高血压合并左室肥厚的患者，观察左室重构逆转效果及心功能改善情况。

1资料与方法

1.1病例选择选取2012年8月至2014年09月在我院住院及门诊就诊治疗的原发性高血压患者，经心脏彩超检查合并有左室肥厚的患者115例，随机分为两组，治疗组57例，男29例，女28例，年龄60～79(68.00±3.12)岁；对照组58例，男28例，女30例，年龄60～81(69.00±3.21)岁。两组间病人一般资料如性别、年龄、病程、基础血压、心脑肾并发症等无统计学差异；心脏彩超检查左室舒张末期内径(LVEDd)、舒张末期室间隔厚度(IVST)、左室舒张末期后壁厚度(LVPWT)、左室射血分数(LVEF)及E/A比值等差异无统计学意义(P>0.05)。