降低循环AngⅡ,通过中枢层面减少交感神经活性的同时也不排除能够降低压力反射重调定从而进一步易化BRS。③抗动脉粥样硬化作用。大量研究证实,四逆汤能明显降低载脂蛋白B,增加载脂蛋白A(apoA)含量,从而减缓动脉粥样硬化程度,使斑块面积缩小,减轻内膜增厚水平,且其抗动脉粥样硬化作用与四逆汤剂量呈一定的量效依赖关系[10,11]。BRS减弱与其感受器敏感性降低有密切相关性,BRS的感受器位于颈总动脉末端和颈内动脉起始处的膨大部分,高血压发生颈动脉粥样硬化的几率很高,因此四逆汤也有可能是通过减低颈动脉粥样硬化,增加感受器敏感性,从而达到易化BRS的作用。

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(本文编辑郭怀印)

肢体缺血预处理对脑缺血再灌注大鼠海马内源性神经干细胞增殖的影响

李 娜1,李光来2,张晓敏2,薛国芳2,李 满2,冯 鹏2