瑞舒伐他汀联合丹参川芎嗪注射液治疗不稳定型心绞痛的疗效及对CRP和血脂的影响

姚晓东

摘要:目的 探讨和分析瑞舒伐他汀联合丹参川芎嗪注射液治疗不稳定型心绞痛的疗效及对C反应蛋白(CRP)和血脂的影响。方法 选取本院2013年4月—2015年3月收治的不稳定型心绞痛患者140例,随机分为对照组和试验组,每组70例。对照组患者给予瑞舒伐他汀治疗,试验组在对照组基础上加用丹参川芎嗪注射液治疗,比较治疗前后两组患者C反应蛋白和血脂变化情况,并比较两组患者治疗效果。结果 两组治疗后总胆固醇(TC)、低密度脂蛋白胆固醇(LDL C)、三酰甘油(TG)和CRP水平明显降低,高密度脂蛋白胆固醇(HDL C)水平增高,但试验组血脂及CRP水平改善明显优于对照组,差异有统计学意义(P <0.05)。试验组患者总有效率为95.71% ,对照组总有效率为87.14% ,试验组总有效率明显高于对照组(P<0.05)。结论 瑞舒伐他汀联合丹参川芎嗪注射液治疗不稳定型心绞痛可以明显降低血脂及C反应蛋白浓度,治疗效果明显。

关键词:不稳定型心绞痛;瑞舒伐他汀;丹参川芎嗪注射液;C反应蛋白;血脂

中图分类号:R541.4 R256.2

文献标识码:A

doi:10.3969/j.issn.1672-1349.2015.12.003

文章编号:1672-1349(2015)12-1367-03

Abstract:Objective To To explore the effect of rosuvastatin combined salvia miltiorrhiza ligustrazine injection on levels of blood lipid and Creactive protein(CRP)in patients with unstable angina pectoris.Methods From April 2013 to March 2014,140 cases of patients with unstable angina pectoris treated in our hospital were collected,all of these patients were randomly divided into two groups:Control group(n=70)treated with rosuvastatin and experiment group(n=70)treated with rosuvastatin plus salvia miltiorrh-i za ligustrazine injection treatment.The levels of blood lipid and Creactive protein in patients with unstable angina pectoris were measured,and the clinical treatment effect was compared.Results After treatment,compared to control group,levels of TG,LDL C,TC and CRP were significantly decreased(P<0.05).The total effective rate of treatment group was 95.71%,which was higher than 87.14% of the control group(P<0.05).Conclusion Rosuvastatin plus salvia miltiorrhiza ligustrazine injection can decrease levels of blood lipid and Creactive protein,and the effective rate was significance.

作者单位:山东中医药大学附属医院(济南250014),Email: yxd766599@163.com

Effect of Rosuvastatin and Salvia Miltiorrhiza Ligustrazine Injection on the Levels of Blood Lipid and CRP in Patients with Unstable Angina Pectoris

Yao Xiaodong

The Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014,Shandong,China

Key words:unstable angina pectoris;rosuvastatin;salvia miltiorrhiza ligustrazine injection;Creactive protein;blood lipid

冠心病是目前心血管疾病中发病率和死亡率均很高的疾病之一,是由于冠状动脉血管发生粥样硬化病变而造成的血管腔狭窄或阻塞,进而导致心肌缺血、缺氧或坏死[1,2]。不稳定型心绞痛是介于稳定型心绞痛和心肌梗死之间的一种临床状态,疼痛感强,发病率高,严重者甚至危及患者生命[3]。不稳定型心绞痛具有独特的病理机制,若得不到及时有效的治疗会严重影响患者预后。丹参川芎嗪注射液对血管内皮具有保护作用,抑制自由基的生成[4]。……