周 丽

【摘 要】目的：探究姑息性化疗对中晚期肺癌患者生存状态的干预作用。方法：选择2011年9月～2015年8月期间在我院治疗的150例中晚期肺癌患者，随机均分为两组，即观察组给予姑息性化疗，对照组给予辅助性治疗，再比较两组综合疗效。结果：观察组生存率为80.0%显著高于对照组，（P<0.05）；治疗3周期后观察组KPS评分、5个功能量表、整体生活质量量表（GOL）高于对照组；单项测量项目与症状量表均低于对照组（P>0.05）；观察组BMI、Alb、TRF及PA均高于对照组，Hb低于对照组（P>0.05）；1年后对两组存活与未存活患者分别给予QLQ-C30量表、KPS评分与营养状况评估。生存患者GOL评分、KPS评分及Alb含量均高于未生存患者，具有统计学差异，P<0.05。结论：中晚期肺癌患者经姑息性化疗治疗，可有效提高生存率。可通过GOL评分、KPS评分与Alb预测肺癌患者生存期。

【关键词】姑息性化疗；中晚期肺癌；生存状态；干预

The intervention effect of Palliative Chemotherapy on the survival state of locally advanced lung cancer patients

【Abstract】Objective：To explore the intervention effect of Palliative Chemotherapy on the survival state of locally advanced lung cancer patients.Methods：From September in 2011 to August in，150 cases of middle-late stage lung cancer patients treated in the hospital were chose and randomly divided into two groups.The observation group was given palliative chemotherapy，and the control group was given adjuvant treatment，then comprehensive curative effects of two groups were compared.Results：The survival rate of the observation group（80.0%）was significantly higher than the control group（P<0.05）.After 3 cycles of treatment，KPS score，five function scale，the overall quality of life scale（GOL）of the observation group were higher than the control group.Single measurement project and symptom score were lower than the control group（P>0.05）.BMI，ALB，TRF and PA of the observation group were higher than that of control group，and the Hb is lower than the control group（P>0.05）.A year later，GOL score，KPS score and ALB content of the survival patients were all higher than the none survival patients，with statistically difference（P<0.05）.Conclusion：The palliative chemotherapy can effectively improve the survival rate of the middle-late stage lung cancer patients.And the survival time of the patients with lung cancer could be predict by GOL score，KPS score and ALB.

【Keywords】Palliative chemotherapy；Middle-late stage lung cancer；Living condition；Intervention

當今随着大气污染逐渐加重，肺癌发病率也显著提高。给予肺癌患者早期手术可根治，但超过80%患者就诊时属于中晚期，治愈几率较低[1]。现临床主要采用放疗及化疗手段，可有效缩小肿块，延长生存时间，但其毒副作用会严重影响患者生存质量，因此患者及家属对姑息性化疗治疗存在顾虑。本研究旨在探究姑息性化疗对中晚期肺癌患者生存状态的影响与相关影响因素。现报告如下：

1资料与方法

1.1一般资料 在2011年9月～2015年8月于我院接受治疗的150例中晚期肺癌患者中，男103例，女47例，年龄为42～82岁，平均年龄为（62.4±8.4）岁。，排除糖尿病、心血管疾病以及精神疾病等慢性疾病患者。随机将患者分为观察组与对照组，各75例，且在一般资料上无统计学差异，P>0.05。

1.2评定方法 每3周均需评定患者生存率及各项指标，及时了解患者生存质量情况，连续评定3周期。采用KPS量表、QLQ-C30评定患者治疗后营养情况。测量并……