蒋倩等

[摘要] 通过文献检索，查阅近十年来发表的有关大肠癌证型分布及生物学基础研究的文献，总结证型分布特征及生物学基础，结果发现，大肠癌常见中医证型以及所涉及分子生物学基础分别是：大肠癌湿热蕴结证和气血亏虚证患者与正常人的蛋白质表达有差异；VEGF、EGF基因表达差异可作为大肠癌脾气亏虚证客观量化的参考指标之一；大肠癌瘀血内证患者与外周血PTEN、CD的表达存在相关性；大肠癌肝肾阴虚证的分子基础涉及组建炎性细胞因子网络。大肠癌的常见证型的分布以及相关分子生物学的研究，可能有助于更好地理解用中医的证治疗癌症的现代策略。

[关键词] 大肠癌；证候；生物学基础

[中图分类号] R734 [文献标识码] A [文章编号] 1673-7210（2015）06（b）-0028-04

Research progress on colorectal cancer syndrome distribution characteristics and biological basis

JIANG Qian1，2 HUO Jiege3 WANG Xiaoning3

1.The First School of Clinical Medicine， Nanjing University of Chinese Medicine， Jiangsu Province， Nanjing 210038， China； 2.Hai'an county Huji Hospital， Jiangsu Province， Hai'an 216600， China； 3.Jiangsu Province Academy of Traditional Chinese Medicine， Jiangsu Province， Nanjing 210028， China

[Abstract] According to literature review， refer to the literature about the syndrome distribution and biology of colorectal cancer published in recent ten years， summarize syndromes distribution characteristics and biological basis. The results showed that the syndrome distribution and the involved biological basis of colorectal cancer are as follow： there are different between patients with accumulation of damp heat syndrome and deficiency of Qi and blood deficiency and normal people in protein expression； VEGF， EGF gene expression can be used as a reference index of quantitatively evaluating the colorectal cancer patients of temper deficiency； there is a correlation between the PTEN， CD expression of peripheral blood and colorectal cancer patients of blood stasis； molecular basis of colorectal cancer patients of Yin deficiency of liver and kidney relates to the formation of inflammatory cytokine network. Study of the distribution of common type of syndrome of colorectal cancer and mosquito-related molecular contributes to a better understanding of modern strategy of treating cancer using syndrome of traditional Chinese medicine.

[Key words] Colorectal cancer； Syndrome； Biological basis

大肠癌是指原发于结肠、直肠的恶性肿瘤。近年来，发病率日渐攀升[1]，当前，发病率居我国恶性肿瘤增长首位[2]。中医药的干预，不仅可改善患者临床症状，与放化疗结合可增敏减毒，在提高机体免疫力、预防复发转移等方面有重要作用。大肠癌属中医学“肠痈疽”、“便血”等的范畴，历代相关文献中对此有详细记载[3]。中医药在治疗大肠癌方面积累了丰富的经验。但是，目前缺乏统一的辨证分型标准，这不利于大肠癌的中医药规范化治疗及普及。本文系统对大肠癌证候进行分类及分析生物学基础的文献，以初步加深对大肠癌的证候临床分布特点以及潜在的分子生物学基础的了解，进而为开展大肠癌证候学和证候规范化研究提供基础和思路。……