沈旭峰等

[摘要] 目的 探讨综合性护理干预对重组人α-2b凝胶治疗慢性宫颈炎合并HPV感染疗效的影响。 方法 将2013年1月～2014年1月于我院确诊并接受治疗的慢性宫颈炎合并HPV感染的患者100例，采用随机数字表法则分为干预组50例与对照组50例，两组均予重组人干扰素α-2b凝胶进行治疗，干预组在此基础上实施综合性护理干预，对照组予以随机对症护理，比较两组患者治疗后的疗效以及两组患者治疗后异常分泌物持续时间及身体功能、心理功能、社会功能、物质生活四个维度的生活质量评分。 结果 干预组治疗后治愈27例、好转20例、无效3例，总有效率达94.0%；对照组治疗后治愈24例、好转16例、无效10例，总有效率达80.0%，两组总有效率比较，差异具有统计学意义（P<0.05）。干预组患者治疗后异常分泌物持续时间明显短于对照组，差异具有统计学意义（P<0.05）。干预前两组的生活质量评分中身体功能、心理功能、社会功能、物质生活四个维度评分组间比较，无统计学意义（P>0.05），干预后两组生活质量评分中的身体功能、心理功能、社会功能、物质生活四个维度评分均较干预前显著提高，且干预组显著高于对照组，差异具有统计学意义（P<0.05）。 结论 综合性护理干预可以提高重组人α-2b凝胶治疗慢性宫颈炎合并HPV感染的疗效，改善临床症状，提高患者的生活质量。

[关键词] 综合性护理干预；重组人α-2b凝胶；慢性宫颈炎合并HPV感染；疗效；生活质量

[中图分类号] R711.3；R473.71 [文献标识码] B [文章编号] 1673-9701（2015）09-0136-04

The impact of comprehensive nursing intervention on recombinant human alpha -2b gel in the treatment of chronic cervicitis combined HPV infection

SHEN Xufeng1 YE Yinli2 XU Jinjin2 ZHONG Xingwei3

1.Infection Management Department， Cixi City Traditional Chinese Medicine Hospital， Cixi 315300，China； 2.Gynecology Department， Cixi City Traditional Chinese Medicine Hospital， Cixi 315300， China； 3.Science and Technology Department，Cixi City Traditional Chinese Medicine Hospital，Cixi 315300，China

[Abstract] Objective To explore the effect of comprehensive nursing intervention for recombinant human alpha -2b gel in treatment of chronic cervicitis with HPV infection. Methods A total of 100 chronic cervicitis incorporated with HPV infected patients from January 2013 to January 2014 in our hospital diagnosed and treated patients， according to the random number table rule divided into intervention group 50 cases and control group 50 cases， two groups were treated by recombinant human interferon alpha -2b gel treatment， the intervention group on the basis of implementing comprehensive nursing intervention，the control group was treated with random and symptomatic care，curative effect was compared between the two groups after treatment，and abnormal discharge duration，physical function，psychological function，social function，quality of life score of four dimensions of material life were compared between the two groups after treatment. Results After treatment，27 cases were cured，20 cases were better，3 cases were invalid，the total effective rate was 94% in the intervention group； the control group after treatment， 24 cases were cured，16 cases were better，10 cases were invalid，the total effective rate was 80%，the total efficiency of two groups were compared，the difference was significant between two groups（P<0.05）. Patients in the intervention group after the treatment of abnormal discharge duration was significantly shorter than that in the control group， with significant difference（P<0.05）. The function of the body， the quality of life score of the two groups before the intervention of psychological function，social function，four dimensions of material life scores were compared between two groups， with no statistical significance（P>0.05）.Quality of life score of two groups after the intervention of physical function，psychological function，social function，four dimensions of material life scores improved significantly before intervention，and the intervention group was significantly higher than that of the control group， with significant difference（P<0.05）. Conclusion The comprehensive nursing intervention can improve the effect of recombinant human alpha-2b gel in treatment of chronic cervicitis with HPV infection and improve the clinical symptoms，improve the quality of life of patients.

[Key words] Comprehensive nursing intervention； Recombinant human alpha-2b gel； HPV infection； Chronic cervicitis； Curative effect； Quality of life

慢性子宫颈炎（chronic cervicitis）是妇科的常见病、多发病，多在妇科手术或妇女病普查体检时发现。慢性宫颈炎主要表现为白带增多、腰骶部疼痛、性交痛及接触性出血，严重时可并发输卵管炎、不孕等，严重影响患者的生活质量[1]。近年来对人乳头状瘤病毒（human papillomavirus，HPV）感染研究较多，流行病学及分子生物学研究资料表明，HPV感染与宫颈癌及癌前病变密切相关，高危型HPV感染是导致宫颈癌的主要病因，而且HPV与宫颈糜烂两者都被认为是宫颈癌的高危因素。……