董建龙　综述　白　松　审校

作者单位：昆明医科大学第一附属医院　干疗科　650032

AIM2在结直肠癌发生发展中机制的研究进展

董建龙综述白松审校

作者单位：昆明医科大学第一附属医院干疗科650032

【摘要】黑素瘤缺乏因子2(absentinmelanoma 2，AIM2)是一种细胞质的蛋白质，能够通过PYD(pyrin domain)结构域与接头蛋白(apoptosis-associated speck-like protein containing a CARD，ASC)相互作用。一旦感知到了胞质dsDNA之后，AIM2就会募集到ASC产生出炎症复合体，进而激活了caspase-l，促进炎性细胞因子成熟与分泌。AIM2还能够感受到胞质与核内dsDNA所发出的不同天然免疫应答，诱导生成干扰素-β和炎性细胞因子。研究表明，AIM2是一种肿瘤抑制因子，因为在许多恶性肿瘤中，如黑色素瘤、结直肠癌和前列腺肿瘤，AIM2表达存在降低或缺失；同时研究表明结直肠癌患者肿瘤细胞中AIM2表达缺失与其预后不良密切相关，但研究人员并不清楚AIM2如何影响肿瘤的发生。最近一些团队研究了AIM2在结直肠癌发生发展中的作用，本文就对此进行总结。

【关键词】AIM2结直肠癌AKT肠干细胞肠道菌群

doi:10.3969/j.issn.1672-4860.2015.06.040

【Abstract】Absent in melanoma 2 (AIM2) is a cytoplasmic protein，can through the PYD (pyrin domain) and the adaptor protein (ASC) interaction.Once the perceived cytoplasmic dsDNA,AIM2 will be raised to ASC produce inflammation complex，activation of Caspase-l，and promote the inflammatory cytokines in the matration and secretion. AIM 2 also can feeld iferent natural immuneresponse by cytoplasmic and nuclear dsDNA, induced by cytokines and inflammatory produce INF-β. Research also suggests that AIM2 is a tumor suppressor because its expression is turned down or off in many melanomas, colorectal cancers, and prostate tumors; lack of AIM2 expression in tumor cells is closely associated with poor survival in colorectal cancer patients. However, researchers don’t know precisely how AIM2 affects tumorigenesis, so some teams investigated its role on the development of colorectal cancer.This review will summarize this.

收稿日期：2015-11-13

Research advances in the mechanism of AIM2 in the development of colorectal cancer(DONGJianlong,BAISong.Dept.oftherapy,The1staffiliatedhospitalofKunmingmedicaluniversity,Kunming650032,China.)

【Key words】AIM2, Colorectal Cancer, Akt, Intestinal Stem Cells, Intestinal Microflora

结直肠癌是世界常见的肿瘤之一，流行病学统计资料显示，在恶性肿瘤中，全球结直肠癌发病率男性位于第四位，女性位于第三位，每年大约有100万新发病例，发达国家的死亡率近33%，且有逐年增长趋势，对人类健康造成极大威胁[1,2]。国外研究报道早期结直肠癌5年生存率达80%，而晚期结直肠癌5年生存率不到10%，但只有近40%的结直肠癌患者能够在早期诊断，可见早期诊断及预防结直肠癌的重要性[3,4]。

AIM2是近些年来新发现的一种模式识别受体，能够感受DNA病毒或细菌感染时释放到细胞浆的dsDNA,经ASC活化Caspase-1，促进IL-1β和IL-18成熟释放，或诱导细胞凋亡。……