郭芳+郭素芹+朱俊敬

doi：10.3969/j.issn.1007-614x.2014.15.6

基金项目 河南省重大科技攻关项目资助（编号：082102310037）

摘 要 目的：研究儿童精神分裂症首发患者病前行为特征与事件相关电位的关系。方法：采用Achenbach儿童行为量表，回顾性调查儿童精神分裂症首发患者在6～11岁时的行为特征。采用事件相关电位P300对患者的认知功能进行评估。用t检验比较CBCL量表高分组与低分组患者治疗前后P300各数据间的差别。结果：研究组与对照组CBCL量表社会能力总分、行为问题总分、抑郁因子分、社会退缩因子分、攻击性因子分之间差异具有统计学意义（Z=-2.820，-2.325，-2.561，-2.837，-2.759；P<0.05），社会能力总分与治疗前P300潜伏期呈负相关（r=-0.231，P<0.05）。结论：首发儿童精神分裂症患者病前社会能力与认知功能存在相关关系，社会能力较低的患者认知功能损害较严重。

关键词 儿童 精神分裂症 儿童行为量表 事件相关电位

The relationship between event related potentials and the premorbid behavior of the first-episode child schizophrenia

Guo Fang1，Guo Suqin（Corresponding author）1，Zhu Junjing2

Department of Children's Psychiatric，the Second Affiliated Hospital of Xinxiang Medical University，Henan 4530021

Department of Children's Psychiatric，the Eighth People's Hospital of Zhengzhou City，Henan 4500062

Fundation item supported by the key science and technology project of Henan province（No：082102310037）

Abstract Objective：To study the relationship between event related potentials and the premorbid behavior of the first-episode child schizophrenia.We reviewed the behavior characteristics of the first-episode child schizophrenia when they were 6 to 11 years old，who were detected by Achenbach Child Behavior Checklist.We assessed the cognitive function of patients by the event-related potential P300.We used t test to compare the difference of each P300 data before and after the treatment between the group with the CBCL scale high achievers and low achievers.Results：The difference of social competence scores，the total score of cbcl，the score of depression factor，the score of social withdrawal factor，the score of aggressive factor of the CBCL scale between the study group and the control group were statistically significant（Z=-2.820，-2.325，-2.561，-2.837，-2.759；P<0.05）.The total score of social capacity and the P300 latency before the treatment was negatively correlated（r=-0.231，P<0.05）.Conclusion：There are some correlation between the social abilities and cognitive function of the first-episode child schizophrenia.The lower of social ability，the more serious damage of cognitive.

Key words Children；Schizophrenia；Child Behavior Checklist；Event related potentials

儿童精神分裂症是常见的儿童期精神疾病之一。研究表明，儿童期起病的患者病前特征较差，其发病前就已存在不同形式和程度的功能紊乱，某些认知领域受损[1]；而ERP-P300作为判定认知功能的指标已得到临床上广泛认可[2]。本研究通过对70例首发儿童精神分裂症患者进行CBCL病前行为特征评估，用P300评定其治疗前后的变化，探讨其病前行为特征与认知功能的关联。

资料与方法

2012年11月-2013年6月收治精神分裂症患儿70例，男34例，女36例，年龄11～15岁，平均（12.33±2.14）岁，病程1～6个月，平均（3.04±2.23）个月。入组标准：①符合DSM-IV分类与诊断标准中精神分裂症的诊断标准；②病程<6个月；③年龄≤15岁。

排除标准：①排除严重躯体疾病和神经系统疾病；……