成静  袁永梅  王宝玉

[摘要] 目的 对埃索美拉唑在老年性胃溃疡患者治疗中的安全性进行分析。 方法 在我院2012~2013年两年接收治疗的老年性胃溃疡患者中选取68例，分成两组，对照组患者采用奥美拉唑进行治疗，观察组患者采用埃索美拉唑进行治疗。对比分析其临床疗效。 结果 观察组患者的临床治疗总有效率为94.1%，对照组为73.5%，差异有统计学意义（P＜0.05）；观察组和对照组患者的Hp根除率分别为88.2%和67.6%，差异有统计学意义（P＜0.05）；观察组和对照组患者的不良反应发生率分别为8.8%和14.7%，差异有统计学意义（P＜0.05）。 结论 采用埃索美拉唑治疗老年性胃溃疡，有助于提高临床治疗有效率，降低不良反应的发生，具有较高安全性，值得推广。

[关键词] 老年性胃溃疡；埃索美拉唑；安全性

[中图分类号] R537.1   [文献标识码] B   [文章编号] 2095-0616（2014）08-73-03

Analysis of application safety of esomeprazole in treatment of elderly patients with gastric ulcer

CHENG Jing  YUAN Yongmei  WANG Baoyu

Department of Emergency, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China

[Abstract] Objective To analyze the safety of esomeprazole in the treatment of elderly patients with gastric ulcer. Methods Sixty-eight elderly patients with gastric ulcer treated in our hospital from 2012 to 2013 were divided into two groups. The control group received omeprazole treatment and the observation group received esomeprazole treatment. The clinical efficacy of the two groups was analyzed comparatively. Results The clinical total effective treatment rate of the observation group was 94.1% and that of the control group was only 73.5%, with significant difference (P＜0.05); The Hp elimination rates of the observation group and the control group were 88.2% and 67.6% respectively, with significant difference (P＜0.05); The incidences of adverse reactions of the observation group and the control group were 8.8% and 14.7% respectively, with significant difference (P＜0.05). Conclusion The application of esomeprazole in the treatment of elderly patients with gastric ulcer is conducive to improving the clinical effective treatment rate and reducing the occurrence of adverse reactions and has high safety, thereby worthy of promotion.

[Key words] Elderly patients with gastric ulcer; Esomeprazole; Safety

胃溃疡是一种常见的消化道疾病，可发生于食管、胃或十二指肠，也可发生于含有胃黏膜的Meckel憩室内，多发于冬春两季，且男性患者多于女性患者。随着我国人口老龄化加剧，加上老年人的胃黏膜防护能力、黏膜供血功能不断下降，使得老年性胃溃疡患者人数在逐年增加，严重影响老年患者的生活质量[1]。为此，本文特选取本院收治的68例老年性胃溃疡患者，研究埃索美拉唑的临床疗效，现报道如下。

1 资料与方法

1.1 一般资料

选取我院2012~2013年两年以来收治的68例老年性胃溃疡患者，所有患者均经胃镜确诊为活动性胃溃疡，排除胃癌等。随机将其分为对照组及观察组，各34例，对照组男24例，女10例，年龄62~75岁，平均（68.5±6.5）岁，溃疡位置：13例胃窦大弯，16例胃窦小弯，5例胃窦前壁；……