杜艳玲  曾伶俐

[摘要] 目的 观察喜炎平联合山蜡梅叶颗粒治疗小儿手足口病（普通型）的临床疗效。方法 将本院收治的120名小儿普通型手足口病患儿分为治疗组和对照组，治疗组应用喜炎平联合山蜡梅叶颗粒进行治疗，对照组应用单一喜炎平注射液肌注进行治疗，比较两组患儿临床治疗效果等指标。结果 治疗组的总有效率（93.3%）明显高于对照组（78.3%）（P＜0.05）。结论 喜炎平联合山蜡梅叶颗粒治疗小儿普通型手足口病具有良好的疗效，值得临床推广。

[关键词] 喜炎平；山蜡梅叶颗粒；手足口病

[中图分类号] R725.1   [文献标识码] B   [文章编号] 2095-0616（2014）08-66-03

Observation of clinical efficacy of Xiyanping combined with chimonanthus nitens leaf particles in treatment of children with hand-foot-mouth disease(ordinary type)

DU Yanling  ZENG Lingli

Department of Pediatrics, Zhongshan Dayong Hospital, Zhongshan 528400,China

[Abstract] Objective To observe the clinical efficacy of Xiyanping combined with Chimonanthus nitens leaf particles in the treatment of children with hand-foot-mouth disease(ordinary type). Methods 120 children with ordinary hand-foot-mouth disease treated in our hospital were divided into the treatment group and the control group. The treatment group received Xiyanping combined with Chimonanthus nitens leaf particles for treatment and the control group received intramuscular injection of single Xiyanping for treatment. The clinical treatment effects and other indicators of the two groups of children were compared. Results The total effective rate(93.3%) of the treatment group was significantly higher than 78.3% of the control group(P＜0.05). Conclusion Xiyanping combined with Chimonanthus nitens leaf particles shows good efficacy in the treatment of children with ordinary hand-foot-mouth disease and therefore is worthy of clinical promotion.

[Key words] Xiyanping;Chimonanthus nitens leaf particles;Hand-foot-mouth disease

手足口病（hand-foot-mouth disease，HFMD）又名发疹性水疱性口腔炎，由肠道病毒以柯萨奇A组16型（CoxA16）、肠道病毒71型EV71多见，引起的急性传染病，多发生于学龄前儿童，尤以3岁以下年龄组发病率最高[1]。其症状表现为患儿手部、脚部、口腔等部位发生疱疹，故称手足口病。手足口病流行无明显的地区性。一年四季均可发病，但以夏秋季多见，冬季的发病较为少见。本病常于暴发流行后散在发生，托幼机构是本病流行的主要场所[2]。手足口病是全球性传染病，世界上大部分国家和地区均曾有关于此病流行的报道。多数患儿病情较轻，但是，有些患儿病情进展迅速，易引发一系列诸如心肌炎、肺水肿、无菌性脑膜脑炎在内的并发症，甚至可能危及患儿的生命。为了做好手足口病的防治工作，卫生部在2010年发布了《手足口病诊疗指南》，其中提出可以运用中西医药物结合进行抗病毒治疗。……