罗志丽  谭 峰  吴玉华  杨小海  李志英  陈尚萍

[摘要] 目的 探讨血必净在产科高凝状态中的临床预防治疗效果。 方法 选择2011年6月~2013年6月住院的72例重度子痫前期患者作为研究对象，系统随机化法将其分为两组，对照组（36例）术后静脉滴注葛根素治疗，观察组（36例）术后静脉滴注血必净治疗，比较两组生产前后的凝血指标。 结果 观察组产后纤维蛋白原和血细胞积压两个指标值均明显下降（P＜0.05），D-二聚体指标平均值上升，但差异无统计学意义（P＞0.05）；对照组产前、产后血细胞积压、纤维蛋白原及D-二聚体3项标准均未见明显差异（P＞0.05）。 结论 血必净在预防治疗重度子痫前期高凝状态的临床效果显著，值得临床借鉴推广。

[关键词] 重度子痫前期；高凝状态；血必净；产科；凝血功能障碍

[中图分类号] R714   [文献标识码] B   [文章编号] 2095-0616（2014）08-58-03

Clinical research of Xuebijing in the treatment of obstetric hypercoagulable state

LUO Zhili  TAN Feng  WU Yuhua  YANG Xiaohai  LI Zhiying  CHEN Shangping

Department of Obstetrics, Maoming People's Hospital, Maoming 525000, China

[Abstract] Objective To investigate clinical preventive effect of Xuebijing in the treatment of obstetric hypercoagulable state. Methods 72 cases of patients with severe preeclampsia were selected as research object, who accessed in our hospital from June 2011 to June 2013.The patients were divided into 2 groups, according to system randomization method. Puerarin was taken by the control group(36 cases) with intravenous infusion. Xuebijing was taken by the observation group(36 cases) with intravenous infusion. Coagulation parameters of both groups were then observed and compared. Results Postnatal fibrinogen and blood cells backlog of observation group significantly decreased(P＜0.05). D-dimer average value increased, but p value exceeded 0.05, so there was no statistical difference. Blood cells backlog, fibrinogen and D-dimer of control group in prenatal and postnatal had no significant difference(P＞0.05). Conclusion Xuebijing has a significant clinical preventive effect in the treatment of severe preeclampsia hypercoagulable state, which is worthy of clinical promotion.

[Key words] Severe preeclampsia; Hypercoagulable state; Xuebijing; Obstetric; Coagulopathy

子痫前期是产科常见妊娠期疾病，相关报道指出其发病率越全部妊娠的4.0%，作为妊娠期高血压疾病的状况之一，其对孕妇及其胎儿的健康均造成了影响[1]。该病在临床上可以分成轻度子痫前期和重度子痫前期，后者机体的凝血和纤溶系统平衡发生失调，凝血功能障碍更加突出，因此血栓形成倾向更加明显。临床研究认为该病的发病机制相对复杂，血管痉挛、一氧化氮、内皮素、内皮细胞激活、血管相关蛋白等均和子痫发作存在关联，临床表现为血压持续上升、蛋白尿、水肿等，病情严重的可造成多器官如心脏、肾脏、肝脏和脑部损伤，因此临床产科对该病的重视程度也不断增高[2]。……