杜东阳　闫海华

[摘要] 目的 探讨氯吡格雷联合辛伐他汀治疗不稳定型心绞痛的临床效果。 方法 选择本院收治的100例不稳定型心绞痛患者，随机分为观察组和对照组，每组各50例。两组均给予常规治疗，对照组给予辛伐他汀治疗，观察组给予辛伐他汀联合氯吡格雷治疗。疗程为8周，观察两组患者治疗前后白细胞介素-6和超敏C反应蛋白水平改变情况。 结果 观察组的白细胞介素-6、超敏C反应蛋白水平与对照组比较，差异有统计学意义，总有效率高于对照组（P<0.05）。 结论 氯吡格雷联合辛伐他汀能够降低不稳定型心绞痛患者白细胞介素-6和超敏C反应蛋白水平，治疗效果显著，值得借鉴。

[关键词] 不稳定型心绞痛；氯吡格雷；辛伐他汀；白细胞介素-6；超敏C反应蛋白

[中图分类号] R542.2+2 [文献标识码] A [文章编号] 1674-4721（2014）04（a）-0092-03

[Abstract] Objective To explore the clinical effect of clopidogrel combined with simvastatin treating unstable angina pectoris. Methods 100 patients with unstable angina pectoris were selected and randomly divided into the observation group （n=50） and the control group （n=50）.The two groups were given conventional treatment，and the control group was given simvastatin while the observation group was given simvastatin combined with clopidogrel.The course was 8 weeks. The change of interleukin-6 and high sensitivity C-reactive protein level were observed before and after treatment. Results The level of interleukin-6 and high sensitivity C-reactive protein in the observation group compared with those in the control group，and there was a statistical difference of the two groups；the total effective rate of the observation group was higher than that in the control group （P<0.05）. Conclusion Clopidogrel and simvastatin can decrease the level of interleukin -6 and high sensitivity C-reactive protein in patients with unstable angina pectoris and the treatment effect is significant.It is worthy of reference.

[Key words] Unstable angina pectoris；Clopidogrel；Simvastatin；Interleukin -6；High sensitivity C-reactive protein

不稳定型心绞痛容易发展为心肌梗死，甚至可导致猝死，严重威胁患者的健康。血栓研究中发现，血小板活化是其形成的重要因素，与不稳定型心绞痛的发生、发展关系密切。氯吡格雷有抗血小板作用，辛伐他汀属于调脂类药物。本研究选择本院收治的不稳定型心绞痛心绞痛患者，观察氯吡格雷联合辛伐他汀对此类患者的治疗效果及对相关炎性因子水平的影响。

1 资料与方法

1.1 一般资料

选取本院2010年9月～2013年9月收治的100例不稳定型心绞痛患者，患者符合不稳定型心绞痛诊断标准，反复发作，心电图检查提示心电图ST-T段改变，同时排除合并甲状腺功能亢进症、糖尿病、妊娠期及哺乳期、重度心律失常、严重肝肾疾病及心力衰竭、急性心肌梗死、出血性疾病患者。将患者随机分为观察组与对照，每组各50例。……