朱进峰　简亚梅

[摘要] 目的 探讨盐酸氨溴索治疗慢性支气管炎急性发作的临床效果。 方法 将本院2012年2月～2013年10月收治的90例慢性支气管炎急性发作患者，随机分为对照组和观察组，每组各45例。两组患者均给予常规治疗，对照组加用盐酸溴己新注射液治疗，观察组加用盐酸氨溴索注射液治疗，比较两组患者的临床效果和不良反应。 结果 观察组患者的总有效率为95.6%，明显高于对照组的75.6%（P<0.05）；治疗后，观察组患者的PaO2升高，PaCO2降低，与对照组比较，差异有统计学意义（P<0.05）；两组的不良反应发生率比较，差异有统计学意义（P<0.05）。 结论 盐酸氨溴索治疗慢性支气管炎急性发作的临床效果较为显著，不良反应轻微，值得推广应用。

[关键词] 盐酸氨溴索；慢性支气管炎；急性发作

[中图分类号] R562.2+1 [文献标识码] A [文章编号] 1674-4721（2014）04（a）-0067-02

[Abstract] Objective To explore the clinical effect of ambroxol hydrochloride treating acute exacerbation of chronic bronchitis. Methods 90 patients with acute exacerbation of chronic bronchitis were treated in our hospital from February 2012 to October 2013，and they were randomly divided into the control group and the observation group，there were 45 cases in each group.Patients of the two groups were given conventional treatment，the control group was added in bromhexine hydrochloride injection treatment，the observation group was added in ambroxol hydrochloride injection treatment，the clinical effect and adverse reaction of patients in the two groups were compared. Results The total effective rate of patients in the observation group （95.6%） was significantly higher than that in the control group （75.6%） （P<0.05）；after treatment，PaO2 of patients in the observation group was increased and PaCO2 was decreased，and there was a statistical difference compared with the control group （P<0.05）； there was a statistical difference of the adverse reaction between the two groups （P<0.05）. Conclusion Ambroxol hydrochloride treating acute exacerbation of chronic bronchitis has the more significant clinical effect with mild adverse reactions.It is worthy of popularization and application.

[Key words] Ambroxol hydrochloride；Chronic bronchitis；Acute exacerbation

慢性支气管炎是由于感染或非感染因素引起气管、支气管黏膜及其周围组织的慢性非特异性炎症[1]，慢性支气管炎急性发作是临床常见病，以老年患者最为多见，易反复发作，多病程较长，多在冬季发作[2]，治疗主要以控制感染和祛痰、镇咳为主[3]。盐酸氨溴索可促进呼吸道内部黏稠分泌物的排出及减少黏液的滞留，因而可显著促进排痰。本研究回顾性分析本院收治的90例慢性支气管炎急性发作患者的临床资料，探讨盐酸氨溴索治疗慢性支气管炎急性发作的临床效果。

1 资料与方法

1.1 一般资料

所选研究对象为2012年2月～2013年10月本院收治的90例慢性支气管炎急性发作患者，年龄45～72岁，平均（63.5±2.8）岁，其中男性55例，女性35例，将患者随机分为观察组和对照组，每组各45例。两组患者的年龄、性别、病情严重程度等一般资料比较，差异无统计学意义（P>0.05），具有可比性。

1.2 治疗方法

两组患者均给予常规吸氧、控制感染以及解痉平喘等常规治疗。……