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不同金属烤瓷全冠对龈沟液内可溶性细胞间黏附分子—1及白细胞介素—1β水平的影响

2014-04-10赵宏

中国医药导报 2014年7期

赵宏

浙江省富阳市中医医院口腔科,浙江富阳 311400

[摘要] 目的 通过观察不同合金烤瓷冠修复前后龈沟液(GCF)中可溶性细胞间黏附分子-1(sICAM-1)及白细胞介素-1β(IL-1β)水平变化,探讨不同金属基底烤瓷冠对牙周组织的影响。 方法 将45颗牙分为镍铬合金组、钴铬合金组和金铂合金组,每组15颗,分别进行镍铬合金、钴铬合金和金铂合金PFM全冠修复。在治疗前及治疗后6个月检测受试牙菌斑指数(PLI)、龈沟出血指数(SBI)、龈沟探诊深度(GCD)、龈沟内GCF量和sICAM-l、IL-1β水平。 结果 镍铬合金组修复后6个月,SBI、GCD和GCF量和sICAM-l、IL-1β水平[(3.72±0.33)mm、(1.62±0.24)mm、(0.691±0.112)mg、(94.12±25.14)ng/mL、(8.49±3.22)ng/mL]与钴铬合金组[(3.03±0.35)mm、(1.18±0.18)mm、(0.419±0.131)mg、(74.20±26.34)ng/mL、(5.72±3.06)ng/mL]、金铂合金组[(2.21±0.27)mm、(1.42±0.21)mm、(0.325±0.115)mg、(64.89±24.01)ng/mL、(4.24±2.18)ng/mL]相比,差异均有统计学意义(均P < 0.05)。且钴铬合金组修复后6个月,SBI、GCD和GCF量和sICAM-l、IL-1β水平与金铂合金组相比,差异有统计学意义(P < 0.05)。 结论 金铂合金烤瓷全冠对牙周组织的不利影响小于镍铬合金、钴铬合金,钴铬合金优于镍铬合金。

[关键词] 烤瓷熔附金属全冠;龈沟液;可溶性细胞间黏附分子-1;白细胞介素-1β

[中图分类号] R783.3 [文献标识码] A [文章编号] 1673-7210(2014)03(a)-0028-04

Effect of different porcelain-fused-to-metal crown inner metal materials on the level of soluble intercellular adhesion molecule-1 and interleukin-1β in gingival crevicular fluid

ZHAO Hong

Department of Stomatology, Fuyang TCM Hospital of Zhejiang Province, Fuyang 311400, China

[Abstract] Objective To investigate the effect of different alloy porcelain crowns on periodontal tissue by means of measuring the level of soluble intercellular adhesion molecule-1(sICAM-1) and interleukin-1β (IL-1β) in gingival crevicular fluid (GCF) after treatment. Methods A total of 45 teeth were divided into three groups (Ni-Cr alloy group, Co-Cr alloy group and Au-Pt alloy group, 15 teeth of each group), and treated by Ni-Cralloy, Co-Cr alloy and Au-Pt alloy PFM crown according grouping. At the point of pre-restoration, 6 months after cementation, the plaque index (PLI), gingival sulcus bleeding index (SBI) and gingival crevice depth (GCD), GCF and the level of sICAM-1 and IL-1β were detected. Results At the point of 6 months after treatment, SBI, GCD and GCF and the level of sICAM-1 and IL-1β of Ni-Cr alloy group [(3.72±0.33)mm, (1.62±0.24)mm, (0.691±0.112)mg, (94.12±25.14)ng/mL, (8.49±3.22)ng/mL] compared with those in Co-Cr alloy group [(3.03±0.35)mm, (1.18±0.18)mm, (0.419±0.131)mg, (74.20±26.34)ng/mL, (5.72±3.06)ng/mL] and Au-Pt alloy group [(2.21±0.27)mm, (1.42±0.21)mm, (0.325±0.115)mg, (64.89±24.01)ng/mL, (4.24±2.18)ng/mL], there were significant differences (all P < 0.05). At the point of 6 months after cementation, Co-Cr alloy group showed significant difference for SBI, GCD, GCF and the level of sICAM-1 and IL-1β showed significant difference when compared to Au-Pt alloy group (P < 0.05). Conclusion Au-Pt alloy has less bad effect on the periodontal tissue than Ni-Cr alloy and Co-Cr alloy, while Co-Cr alloy has better effect than Ni-Cr alloy.

[Key words] Porcelain-fused-to-metal crown; Gingival crevicular fluid; Soluble intercellular adhesion molecule-1; Interleukin-1β

烤瓷熔附金属全冠(porcelain-fused-to-metal crown,PFM)是在真空高温条件下用低熔烤瓷熔附在合金内冠上形成的一种理想的修复体,兼有金属的强度和瓷的美观,具有形态逼真、色泽稳定、耐酸碱的特点,已被广泛地应用于临床[1-3],但有研究表明,很多患者使用烤瓷冠修复后会出现龈缘黑线、红肿、出血等牙周损伤现象[4-5],严重影响了牙冠修复的效果。本研究通过观察不同合金烤瓷冠修复前后龈沟液(gingival crevicular fluid,GCF)中可溶性细胞间粘附分子-1(sICAM-1)及白细胞介素-1β(IL-1β)水平变化,探讨不同金属基底烤瓷冠对牙周组织的影响,为临床合理选择全冠的制作材料提供参考。……

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