郭倩

[摘要] 目的 探讨沐舒坦联合固尔苏对新生儿呼吸窘迫综合征的临床疗效。 方法 将168例新生儿呼吸窘迫综合征患者分为观察组和对照组，观察组给予沐舒坦联合固尔苏治疗，对照组仅给予固尔苏治疗，观察两组患者治疗24 h后疗效，治疗后12 h、24 h、48 h血气指标及两组患者症状缓解时间、吸氧时间和住院时间。 结果 两组患者治疗24h后有效率分别为71.4%、39.3%；观察组患者治疗24 h、48 h后PaO2均明显大于对照组，而PaCO2均明显小于对照组，两组比较具有显著性差异（P<0.05）；观察组患者症状缓解时间、吸氧时间以及住院时间均明显短于对照组（P<0.05）。 结论 沐舒坦联合固尔苏治疗可以明显改善新生儿呼吸窘迫综合征患者的血气指标，缓解症状，效果好于单用固尔苏治疗。

[关键词] 沐舒坦；固尔苏；新生儿呼吸窘迫综合征

[中图分类号] R722.1 [文献标识码] B [文章编号] 1673-9701（2014）02-0039-02

Effect of ambroxol combined with curosurf in treatment of neonatal respiratory distress syndrome

GUO Qian

Department of Pediatrics， Linquan People's Hospital in Anhui Province， Linquan 410013， China

[Abstract] Objective To investigate the the clinical curative effect on neonatal respiratory distress syndrome by ambroxol and curosurf together. Methods A total of 168 cases of neonatal respiratory distress syndrome were divided into the observation group and the control group， the observation group was given ambroxol and curosurf treatment， while the control group was treated only with curosurf treatment， curative effect after treatment of 24 h， 12 h， 24 h， 48 h blood gas index and two groups of patients symptoms time， oxygen time and the hospitalization time were observed. Results The efficiency treated after 24 h of two groups were 71.4%，39.3%； PaO2 of the observation group treated after 24 h， 48 h were significantly higher than the control group， while PaCO2 was significantly lower than that of the control group， with significant difference（P<0.05）， the symptoms time， oxygen time and hospital time of the observation group patients was significantly less than that of the control group（P<0.05）. Conclusion Ambroxol and curosurf treatment can obviously improve the blood gas indexes in patients with neonatal respiratory distress syndrome， having a good effect than single using of curosurf.

[Key words] Ambroxol； Curosurf； Neonatal respiratory distress syndrome

新生儿呼吸窘迫综合征（Neonatal respiratory distress syndrome，NRDS），即肺透明膜病（HMD），是一种以呼气末肺泡萎陷为特征的特发性疾病，主要由缺乏肺泡表面活性物质（Ps）引起[1]。该疾病常见于早产儿，是导致早产儿死亡的主要原因之一。临床上主要表现为进行性呼吸困难及呼吸衰竭。近年来，随着越来越多早产儿的降生，如何防治该病成为临床工作人员的责任，本研究主要针对这一问题进行了探讨。

1资料与方法

1.1一般资料

选取2012年4月～2013年3月本院新生儿病房收治的NRDS患儿168例，其中男96例，女72例，平均胎龄（30.6±2.0）周，平均体重（2050±200）g；所有患儿入院时均有呼气性呻吟、呼吸困难、吸气三凹征和发绀等症状。将168例患者随机分为观察组和对照组，观察组84例，男48例，女36例，平均胎龄（30.8±2.2）周，平均体重（2070±210）g；对照组84例，男48例，女36例，平均胎龄（30.4±1.8）周，平均体重（2030±206）g。两组患者在性别、胎龄、体重、病情等方面比较无显著性差异，具有可比性。

1.2方法endprint