王霞飞+卜爽剡+吴永良

[摘要] 目的 观察银杏达莫注射液对高血压合并肾功能不全患者血脂及肾功能的影响。 方法 将我院78例高血压肾功能不全患者随机分为对照组（38例）和银杏达莫组（40例），对照组给予常规降压，银杏达莫组在常规降压基础上，给予银杏达莫注射液30 mL，每日1次，疗程为3周，观察两组患者血压、血脂、肾功能的变化，记录其不良反应。结果 银杏达莫组在降低患者24 h尿蛋白排泄量、BUN、Scr，升高HDL-C、Ccr方面均优于对照组（P<0.05）。结论 银杏达莫注射液可改善高血压肾功能不全患者的脂质代谢及肾功能。

[关键词] 银杏达莫；高血压；肾功能不全；血脂

[中图分类号] R277.5 [文献标识码] B [文章编号] 1673-9701（2014）02-0033-03

Effect of ginkgo leaf extract and dipyridamole injection on the renal function and the blood lipid of patients with hypertension complicated with renal insufficiency

WANG Xiafei1 BO Shuangshan1 WU Yongliang2

1.Department of Internal Medicine，the People's Hospital of Dongyang City in Zhejiang Province， Dongyang 322100，China； 2.The Peoples Hosptial of Xinchang County in Zhejiang Province， Xinchang 312500， China

[Abstract] Objective To study the effect of ginkgo leaf extract and dipyridamole injection on the renal function and the blood lipid of patients with hypertension complicated with renal insufficiency. Methods The hypertension complicated with renal insufficiency patients were recruited and randomly assigned to the control group（38 cases） and the ginkgo leaf extract and dipyridamole group（40 cases）. All patients received conventional antihypertensive treatment. but those ni the Ginkgo leaf extract and dipyridamole group received Ginkgo leaf extract and dipyridamole injection 30 mL ivgtt qd additionally. The observation was lasted for 3 weeks. The blood pressure， blood lipid and the indices of the renal functions were observed before and after treatment. Results After 3 weeks of treatment， better effects in reducing the 24 h protein excretion in urine，BUN，Scr and increasing HDL-C，Ccr were obtained in the ginkgo leaf extract and dipyridamole group than in the control group（P<0.05）. Conclusion The ginkgo leaf extract and dipyridamole could postpone the progression of CRI，improve the lipid metabolize.

[Key words] Ginkgo leaf extract and dipyridamole； Hypertension； Renal dysfunction； Blood lipid

高血压是我国最常见的慢性病之一，长期的高血压可引起肾脏小动脉硬化病，肾小管管壁增厚，管腔变窄，进而继发肾实质缺血性损害，高血压已成为导致CRF的主要原因之一。近年来随着高血压患者的逐年上升，高血压导致的肾功能不全患者也呈逐年增加，为此，积极防控高血压肾损害是非常有必要的。研究显示，银杏达莫注射液具有清除自由基、改善微循环和肾血流量等作用[1]，临床主要用于动脉硬化及高血压所致的冠状动脉供血不足、脑缺血等[2]，但对其逆转高血压患者肾损害治疗的相关临床研究较少。因此，基于其药理作用和文献研究的基础上，本研究通过观察银杏达莫注射液对高血压合并肾功能不全患者血脂及肾功能的影响，探讨其临床有效性和安全性，为此类患者的中药治疗提供临床依据。

1资料与方法

1.1入选标准及排除标准

入选标准：所有入选患者均符合2010版《中国高血压防治指南》中高血压的诊断标准[3]，且均有10年以上高血压病病史，并伴有肾功能不全，临床诊断为原发性高血压合并肾功能不全。……