陈艳辉 崔云涛 许英

[摘要] 目的：观察丹参川芎嗪注射液治疗老年脑梗死的临床疗效。方法：选择120例确诊为脑梗死的老年患者，随机将其分为治疗组及对照组，每组各60例。对照组给予丹参注射液静脉滴注，治疗组静脉滴注丹参川芎嗪注射液。观察对比两组患者用药2周后的C反应蛋白变化、临床症状和体征改变、神经功能缺损评分及总有效率。结果：治疗后，两组C反应蛋白和神经功能缺损评分较治疗前均明显下降（Ｐ<0.05或Ｐ<0.01）；治疗组治疗后C反应蛋白较对照组明显下降（Ｐ<0.01），神经功能缺损评分、总有效率均优于对照组（均Ｐ<0.05）。结论：丹参川芎嗪注射液用于治疗急性脑梗死疗效较好，值得临床应用。

[关键词] 丹参川芎嗪；脑梗死；C反应蛋白；神经功能缺损

[中图分类号] R743[文献标识码] A[文章编号]1673-7210（2011）11（c）-115-02

Clinical value on Salvia Miltiorrhiza Ligustrazine Injection in the treatment of elderly cerebral infarction

CHEN Yanhui1, CUI Yuntao2, XU Ying2

1.Department of Cadre Internal Medicine, Siping Hospital of China Medical University, Jilin Province, Siping 136000, China; 2.The First People'sHospital of Siping City, Jilin Province, Siping 136001, China

[Abstract] Objective: To observe the efficacy of Salvia Miltiorrhiza Ligustrazine Injection in the treatment of elderly patients with cerebral infarction. Methods: A total of 120 elderly patients diagnosed as cerebral infarctions were randomly divided into treatment group and control group, each group had 60 cases. The control group was given Salvia Miltiorrhiza Injection with intravenous injection, the treatment group was given Salvia Miltiorrhiza Ligustrazine Injection. The C-reactive protein, clinical symptoms and signs of change, neurological function and the total effective rate of two groups were observed after treatment in 2 weeks. Results: After treatment, C-reactive protein of two groups decreased significantly than before treatment (P<0.05, P<0.01). C-reactive protein of treatment group was better than that of the control group after treatment (P<0.01), the neurological function defect score and the total effective rate of treatment group were all higher than that of the control group after treatment (all P<0.05). Conclusion: Salvia Miltiorrhiza Ligustrazine Injection in the treatment of acute cerebral infarction is better, and worthy of clinical application.

[Key words] Salviae Miltiorrhiza Ligustrazine Injection; Cerebral infarction; C-reactive protein; Nerve function defect

缺血性脑血管病，特别是急性脑梗死的发病率较高，是人类常见致死病因之一[1]。随着社会老龄化的进程逐步加快，老年脑梗死患者有逐年增多的趋势，脑梗死的治疗越来越受到临床医生的重视。笔者对急性脑梗死患者予以丹参川芎嗪注射液治疗，目的是观察丹参川芎嗪注射液治疗老年脑梗死患者的疗效。观察患者用药2周后的C反应蛋白水平的变化，研究应用丹参川芎嗪注射液后临床症状和体征改变、神经功能缺损评分及临床疗效的总有效率的变化。探讨丹参川芎嗪注射液在治疗脑梗死中的临床意义，使更多的老年脑梗死患者在临床治疗中获益。

1 资料与方法

1.1 一般资料

选取2009年10月~2010年5月中国医科大学四平医院住院及少部分门诊患者120例，所有患者均经过临床和ＣＴ、ＭＲＩ确诊为脑梗死，且排除合并有明确精神疾病、严重脏器病变、血管炎与自身免疫疾病、颅内动脉瘤或动静脉畸形等合并症患者。……