张海燕 欧琳华 肖晓冬 吴军峰 叶丽华

[摘要] 目的：探讨痰热清、干扰素交替雾化吸入治疗儿童病毒性肺炎的临床疗效。方法：将100例病毒性肺炎患儿随机分为两组，在常规对症治疗的基础上，治疗组（50例）给予痰热清2.5～5.0 ml/次+生理盐水5～10 ml/次，1～2次/d；并联合干扰素50 000 U/（kg·d）+生理盐水1～2 ml/次，每次10 min，1次/d，两者交替雾化，雾化吸入采用氧驱动化吸入，雾化后予以拍背，促进排痰，5～7 d为1个疗程。对照组（50例）使用利巴韦林10～15 mg/（kg·d）加入5%葡萄糖注射液静脉滴注，2次/d。观察两组治疗后发热、咳嗽、肺部啰音消退时间。结果：两组患儿治疗1周后，治疗组显效36例，有效12例，无效2例，总有效率为96%；对照组显效24例，有效18例，无效8例，总有效率为84%。两组总有效率比较差异有高度统计学意义（P＜0.01），且治疗组咳嗽、发热、肺部啰音等症状消退时间明显短于对照组（P＜0.01）。结论：痰热清、干扰素交替雾化治疗儿童病毒性肺炎在改善症状，缩短病程和提高治疗效果方面明显优于对照组，且用药安全，未发现明显的副作用，值得在临床推广应用。

[关键词] 痰热清；干扰素；雾化吸入；病毒性肺炎；儿童

[中图分类号] R563.1[文献标识码]A [文章编号]1673-7210（2011）11（c）-082-02

Clinical curative effect on Tanreqing, Interferon alternate aerosolized in the treatment of children with viral pneumonia

ZHANG Haiyan, OU Linhua, XIAO Xiaodong, WU Junfeng, YE Lihua

Department of Pediatric, Lianzhou People's Hospital, Guangdong Province, Lianzhou 513400, China

[Abstract] Objective: To investigate the clinical effect on Tanreqing, Interferon alternate aerosolized in the treatment of children with viral pneumonia. Methods: 100 cases of children with viral pneumonia were randomly divided into two groups. On basis of conventional symptomatic treatment, the treatment group (50 cases) was treated with Tanreqing 2.5-5.0 ml/time+NS 5-10 ml/time, 1-2 times/d; and the Interferon 50 000 U/(kg·d)+NS 1-2 ml/time, 10 min/time, 1 time/d. Both groups were taken alternate atomization by using oxygen atomization inhalation and took backslap after atomization inhalation to promote the row of phlegm, 5-7 d for a period of treatment. The control group (50 cases) was given Ribavirin 10-15 mg/(kg·d) to join 5% Glucose Injection, intravenous drip, 2 times/d. The subsidise time of fever, cough, rales of the two groups after treating were observed. Results: One week after treatment, in the treatment group, 36 cases were markedly improved, 12 cases were effective, 2 cases were invalid, the total effective rate was 96%; in the control group, 24 cases were markedly improved, 18 cases were effective, 8 cases were invalid, the total effective rate was 84%. There were significant differences of the total effectiveness between treatment group and control group (P＜0.01), and the cough, fever, and pulmonary symptoms subsided time of treatment group were more shorter than those of control group (P＜0.01). Conclusion: Tanreqing, interferon alternate aerosolized in the treatment of children with viral pneumonia can improve symptoms, shorten course and improve the treatment effect. It is safe and has no significant side effects, it is worthy to be used in clinical.

[Key words] Tanreqing; Interferon; Atomization inhalation; Viral pneumonia; Children

病毒性肺炎是小儿常见的疾病，多见于婴幼儿，以冬春季发病多见，常见呼吸道合胞病毒、腺病毒感染，病情来势凶猛，进展快，病死率相对较高，严重影响患儿的身心健康，目前仍缺乏特异性治疗。我院近年采用痰热清联合干扰素雾化吸入治疗病毒性肺炎100例，取得满意的疗效，且雾化吸入无痛苦，无副作用，易于被患儿及家属接受。……