陈奕权 庄曼茹

[摘要] 目的：观察与分析厄贝沙坦治疗高血压合并慢性肾功能不全的效果。方法：将80例高血压合并慢性肾功能不全患者随机分为两组，即观察组和对照组，每组40例，同时给予两组患者相应治疗措施且对其临床治疗效果、血压控制和肾功能等方面进行观察与相关数据统计分析。结果：观察组治疗总有效率为70%，优于对照组（50%），同时治疗后观察组研究对象收缩压为（135.13±15.34）mm Hg，舒张压为（74.00±8.43）mm Hg，均好于对照组（t=10.75、12.30，均P＜0.05）；观察组血肌酐为（176.0±26.2）μmol/L，尿素氮为（9.7±3.0）mmol/L，尿蛋白为（1.62±0.23）g/24 h，三者均好于对照组（t=11.86、13.84、12.54，均P＜0.05）。结论：厄贝沙坦治疗高血压合并慢性肾功能不全效果显著，不仅可以有效控制血压，同时对改善肾功能，延缓病情进展具有十分重要的临床意义。

[关键词] 厄贝沙坦；高血压；慢性肾功能不全；观察

[中图分类号] R544.1[文献标识码]A [文章编号]1673-7210（2011）11（c）-076-02

Observation and experience of influence on Irbesartan for hypertension and chronic renal insufficiency

CHEN Yiquan, ZHUANG Manru

Department of Internal Medicine, Chaozhou Central Hospital, Guangdong Province, Chaozhou 521000, China

[Abstract] Objective: To observe and analyze the efficacy of Irbesartan in the treatment of hypertension and chronic renal insufficiency. Methods: 80 patients with hypertension and chronic renal failure were randomly divided into two groups, the observation group and control group, with 40 cases in each group. The appropriate treatment was given in two groups and the clinical efficacy, blood pressure control and kidney function of patients in two groups were observed and the data were analyzed. Results: The total effective rate was 70% in the observation group, better than the control group (50%). While after treatment in the observation group, the systolic blood pressure of subject was (135.13±15.34) mm Hg, the diastolic blood pressure was (74.00±8.43) mm Hg, both of which were better than the control group (t=10.75, 12.30, all P＜0.05); the serum creatinine of the observation group was (176.0±26.2) μmol/L, the urea nitrogen was (9.7±3.0) mmol/L, the urinary protein was (1.62±0.23) g/24 h, all of which were better than the control group (t=11.86, 13.84, 12.54, all P＜0.05). Conclusion: The treatment of Irbesartan for hypertension and chronic renal insufficiency has an obvious efficacy. It not only can control the blood pressure effectively, but also has an important clinical significance in improving kidney function and slowing disease progression.

[Key words] Irbesartan; Hypertension; Chronic renal insufficiency; Observation

高血压是指由多种原因造成的体循环动脉收缩压和（或）舒张压持续增高为主要临床特征的一种综合征[1]，据流行病学调查显示[2]，随着社会发展及人们生活方式变化等因素影响，我国高血压的患病率呈现出有增无减的态势。据相关数据统计显示，目前我国高血压病的发病率已达40%～60%，其并发症造成的死亡人数为1 200万。由于高血压病起病隐匿，病程长，因此常常导致良性肾小动脉硬化致使肾内血流异常而造成肾损害，最终导致慢性肾功能不全而对患者生命安全构成极大威胁，鉴于此种情况，笔者此次利用厄贝沙坦治疗高血压合并慢性肾功能不……