胡学升 李晓霞 李建光 陈福佳 王金重

[摘要] 目的 将结肠镜结合腹腔镜用于结肠癌患者治疗中，分析其对患者胃肠功能及免疫功能的影响。 方法 选取2014年5月至2017年8月收治的92例结肠癌患者进行分组研究，随机分成观察组（n=46）与对照组（n=46），对照组行传统开腹手术治疗，观察组行结肠镜结合腹腔镜结肠癌根治术，对两组手术及术后胃肠功能恢复、免疫功能、并发症发生率进行比较。 结果 观察组下床活动时间、肛门排气时间、进流食时间分别为（2.71±0.71）d、（2.23±0.56）d、（2.45±0.58）d，短于对照组（3.52±0.85）d、（3.24±0.63）d、（3.36±0.75）d，两组差异有统计学意义（P<0.05）;观察组术后CD3+、CD4+、CD4+/CD8+水平为（56.15±7.32）%、（48.69±7.25）%、（1.96±0.25）%，高于对照组（34.95±6.31）%、（36.12±6.32）%、（1.45±0.15）%，兩组差异有统计学意义（P<0.05）;观察组术后并发症率为4.34%，低于对照组的19.57%，两组差异有统计学意义（P<0.05）。 结论 对结肠癌患者而言，于结肠镜结合腹腔镜下行结肠癌根治术效果理想，可促进患者胃肠功能尽快恢复，对患者免疫功能影响较小，且并发症较少，值得应用。

[关键词] 结肠镜;腹腔镜;结肠癌根治术;胃肠功能;免疫功能

[中图分类号] R735.35          [文献标识码] B          [文章编号] 1673-9701（2021）24-0062-04

Effects of colonoscopy combined with laparoscopy on gastrointestinal function and immune function of patients undergoing radical resection of early colon cancer

HU Xuesheng   LI Xiaoxia   LI Jianguang   CHEN Fujia   WANG Jinzhong

Department of General Surgery， Jiangmen People's Hospital in Guangdong Province， Jiangmen   529000， China

[Abstract] Objective To apply the colonoscopy combined with laparoscopy in the treatment of patients with colon cancer， and analyze its effects on gastrointestinal function and immune function of patients. Methods A total of 92 patients with colon cancer who were admitted from May 2014 to August 2017 were randomly divided into two groups： the observation group （n=46） and the control group （n=46）. The control group was given traditional open surgery， and the observation group was given colonoscopy combined with laparoscopic radical resection of colon cancer. The recovery of gastrointestinal functions， immune functions and the incidences of complications during and after surgery were compared between the two groups. Results The time of getting out of bed， anal exhaust and fluid feeding in the observation group were （2.71±0.71） d， （2.23±0.56） d and （2.45±0.58） d， respectively， which were shorter than those in the control group， （3.52±0.85） d， （3.24±0.63） d and （3.36±0.75） d， and the differences between the two groups were statistically significant （P<0.05）. The levels of CD3+， CD4+， CD4+/CD8+ in the observation group were （56.15±7.32） %， （48.69±7.25） % and （1.96±0.25） %， respectively， which were higher than the those in the control group， （34.95±6.31） %， （36.12±6.32） % and （1.45±0.15） %， and the differences between the two groups were statistically significant（P<0.05）. The rate of postoperative complications in the observation group was 4.34%， which was lower than 19.57% in the control group， and the difference between the two groups was statistically significant（P<0.05）. Conclusion For patients with colon cancer， colonoscopy combined with laparoscopy for radical resection of colon cancer has an ideal effect， which can promote the recovery of gastrointestinal function as soon as possible， has little impact on the immune function of patients， and has fewer complications， which is worthy of application.