张丹丹 孙百明

摘要：目的  分析硝呋太爾制霉素阴道软胶囊治疗孕妇霉菌性阴道炎的临床疗效及安全性。方法  选取2016年6月29日～2018年6月28日天津市西青医院收治的200例孕妇霉菌性阴道炎患者，按照随机数字表法分为对照组和观察组，各100例。对照组给予制霉素阴道栓治疗，观察组给予硝呋太尔制霉素阴道软胶囊治疗。比较两组临床疗效、不良反应发生情况及临床症状改善时间。结果  观察组治疗总有效率为98.00%，高于对照组的77.00%，差异有统计学意义（P<0.05）。观察组不良反应发生率为2.00%，低于对照组的8.00%，差异有统计学意义（P<0.05）。观察组阴道分泌物增多改善时间、外阴瘙痒改善时间均短于对照组，差异有统计学意义（P<0.05）。结论  采用硝呋太尔制霉素阴道软胶囊治疗孕妇霉菌性阴道炎效果确切，同时具有较高的安全性，并且能够有效改善患者临床症状。

关键词：硝呋太尔;制霉素;孕妇霉菌性阴道炎;安全性

中图分类号：R711.31                                文献标识码：A                                 DOI：10.3969/j.issn.1006-1959.2019.23.047

文章编号：1006-1959（2019）23-0152-02

Therapeutic Effect of Nifuratel Vaginal Soft Capsule on Pregnant Women with Vaginal Vaginitis

ZHANG Dan-dan1，SUN Bai-ming2

（1.Department of Gynecology，Tianjin Xiqing Hospital，Tianjin 300380，China;

2.Department of Urology，Tianjin Nankai Hospital，Tianjin 300030，China）

Abstract：Objective  To analyze the clinical efficacy and safety of nifuratel vaginal soft capsule in the treatment of fungal vaginitis in pregnant women. Methods  A total of 200 pregnant women with fungal vaginitis admitted to Xiqing Hospital of Tianjin from June 29， 2016 to June 28， 2018 were enrolled. The patients were divided into the control group and the observation group according to the random number table method， 100 cases each. The control group was treated with vaginal suppository， and the observation group was treated with nifuratel vaginal soft capsule. The clinical efficacy， adverse reactions and clinical symptom improvement time were compared between the two groups. Results  The total effective rate of the observation group was 98.00%， which was higher than 77.00% of the control group，the difference was statistically significant （P<0.05）. The incidence of adverse reactions in the observation group was 2.00%， which was lower than 8.00% in the control group，the difference was statistically significant （P<0.05）. The improvement time of vaginal secretion and the improvement time of genital itching in the observation group were shorter than those in the control group，the difference was statistically significant （P<0.05）. Conclusion  Nifuratel vaginal vaginal soft capsule is effective in the treatment of fungal vaginitis in pregnant women， and it has high safety and can effectively improve the clinical symptoms of patients.