李廷来

【摘要】 尽管现代医学不断发展，乳腺癌放化疗及手术治疗技术也在革新和发展，但在长期治疗和健康管理中依旧存在药物副作用、放化疗不良反应及肿瘤复发转移等风险。针对以上问题，不少学者专注于中医药研究，尝试将柴胡龙骨牡蛎汤加减方应用于乳腺癌患者早期、放化疗及术后各个阶段的治疗中，实施辨证施治，起到扶正益气、滋阴养血、清热化湿的功效，提高患者临床治疗效率，延长其生存期。本文将简述乳腺癌的病因病机及柴胡龙骨牡蛎汤的相关药理，对近年来柴胡龙骨牡蛎汤加减治疗乳腺癌的研究进行综述，以供参考。

【关键词】 柴胡龙骨牡蛎汤 乳腺癌 手术治疗 副作用 研究进展

Research on the Progress of Chaihu Longgu Oyster Decoction in the Treatment of Breast Cancer/LI Tinglai. //Medical Innovation of China， 2024， 21（15）： -182

[Abstract] Despite the continuous development of modern medicine and the innovation and development of breast cancer radiotherapy， chemotherapy and surgical treatment technology， there are still risks of side effects of drugs， adverse reactions of radiotherapy， chemotherapy and tumor recurrence and metastasis in long-term treatment and health management. In view of the above problems， many scholars focus on the research of traditional Chinese medicine， and try to apply Chaihu Longgu Oyster Decoction to the treatment of breast cancer patients in the early stage， chemotherapy and radiotherapy， as well as in all stages after surgery， to implement treatment based on syndrome differentiation， which has the effect of strengthening vital energy， nourishing Yin and blood， clearing heat and resolving dampness， improving the clinical treatment efficiency of patients and prolonging their survival period. This article will reduce the etiology and pathogenesis of breast cancer and the related pharmacology of Chaihu Longgu Oyster Decoction， and review the research on the treatment of breast cancer with Chaihu Longgu Oyster Decoction in recent years for reference.

[Key words] Chaihu Longgu Oyster Decoction Breast cancer Surgical treatment Side effects Research progress

First-author's address： Department of Pharmacy， Jinan Third People's Hospital， Jinan 250132， China

doi：10.3969/j.issn.1674-4985.2024.15.042

乳腺癌已经成为女性恶性肿瘤发生率最高的疾病，据统计，从2020年起乳腺癌就成了第一大新发癌症，足见其对当代女性生命健康的影响和危害，因此研究并研发治疗乳腺癌的药物和方法也成了当下医学研究的重要课题。柴胡龙骨牡蛎汤是我国传统医学经典方，源自典籍《伤寒论》，书中提到药方可治邪犯少阳、枢机不利及表里三焦之症，后经殷东风深入研究并将其应用于乳腺癌临床治疗中[1]。以上药方主要药材为柴胡、人参、甘草、半夏、黄芩、龙骨和牡蛎，其中人参和甘草主扶正祛邪，半夏、黄芩则能够辛开苦降、寒温并用，加之柴胡、生龙骨、生牡蛎即可调气理气、化痰散结、镇静安神[2]。在基本方基础上，后来各学者实施辨证施治，根据患者实际病情与治疗需求提出不同加减方，达到抗癌、调理、改善治疗效果等功效，下文将具体论述。……