刘世坚

*基金项目：抚州市指导性科技计划项目（抚科社字【2022】9号序号71）

【摘要】 目的：探究盐酸哌罗匹隆联合丁螺环酮治疗难治性精神分裂症的临床效果。方法：将2021年6月—2022年12月抚州市第三医院收治的82例难治性精神分裂症患者根据随机数字表法分为两组。对照组（n=41）采用利培酮联合丁螺环酮进行治疗，观察组（n=41）采用盐酸哌罗匹隆联合丁螺环酮进行治疗。比较两组治疗总有效率、不良反应总发生率，以及治疗前后的阳性和阴性精神症状评定量表（PANSS）评分及社会功能缺陷筛选量表（SDSS）评分。结果：观察组治疗总有效率显著高于对照组，不良反应总发生率显著低于对照组（P<0.05）；治疗前两组PANSS评分及SDSS评分比较，差异均无统计学意义（P>0.05）；治疗6、12周后观察组PANSS评分及SDSS评分均显著低于对照组（P<0.05）。结论：盐酸哌罗匹隆联合丁螺环酮治疗难治性精神分裂症的临床效果较好，安全性较高，可更为显著地改善患者的社会功能。

【关键词】 盐酸哌罗匹隆 丁螺环酮 难治性精神分裂症 社会功能

Clinical Study of Perospirone Hydrochloride Combined with Buspirone in the Treatment of Refractory Schizophrenia/LIU Shijian. //Medical Innovation of China， 2024， 21（15）： 0-062

[Abstract] Objective： To investigate the clinical effect of Perospirone Hydrochloride combined with Buspirone in the treatment of refractory schizophrenia. Method： A total of 82 patients with refractory schizophrenia admitted to Fuzhou Third Hospital from June 2021 to December 2022 were divided into two groups according to random number table method. The control group （n=41） was treated with Risperidone combined with Buspirone， and the observation group （n=41） was treated with Perospirone Hydrochloride combined with Buspirone. The total effective rate， total incidence of adverse reactions and positive and negative syndrome scale （PANSS） scores and strategic decision support system （SDSS） scores before and after treatment were compared between the two groups. Result： The total effective rate of treatment in observation group was significantly higher than that in control group， and the total incidence of adverse reactions was significantly lower than that in control group （P<0.05）. There were no significant differences in PANSS scores and SDSS scores between the two groups before treatment （P>0.05）. After 6 and 12 weeks of treatment， PANSS scores and SDSS scores in observation group were significantly lower than those in control group （P<0.05）. Conclusion： Perospirone Hydrochloride combined with Buspirone in the treatment of refractory schizophrenia has good clinical effect and high safety， which can significantly improve the social function of patients.

[Key words] Perospirone Hydrochloride Buspirone Refractory schizophrenia Social function

First-author's address： Department of Psychiatry， Fuzhou Third Hospital， Fuzhou 344000， China

doi：10.3969/j.issn.1674-4985.2024.15.014

精神分裂症是临床常见的一种精神障碍，其治疗存在一定难度，而本病患者中部分为难治性精神分裂症，其治疗难度相对更大，预后也相对更差，而早期有效的诊治与干预，有助于改善难治性精神分裂症患者的社会功能及疾病负担，对于患者预后的改善意义突出[1-2]。与本病相关的研究显示，认知功能及社会能力均为本病患者亟待改善方面，可作为难治性精神分裂症患者治疗效果的重要评估项目，其对本类患者生存状态及质量的反映意义较高。临床中关于盐酸哌罗匹隆治疗难治性精神分裂症的研究可见，但其研究结果的差异仍普遍存在[3-5]。故本研究现探究盐酸哌罗匹隆联合丁螺环酮治疗难治性精神分裂症的临床效果，以为难治性精神分裂症治疗措施的制订提供参考，报道如下。……