熊菲 朱坤

【摘要】 目的：探究窄谱中波紫外线（NB-UVB）联合左西替利嗪对特应性皮炎患儿嗜酸性粒细胞（EOS）、免疫球蛋白E（IgE）水平的影响。方法：选取九江学院附属医院2020年1月—2023年6月收治的特应性皮炎患儿102例，根据随机数字表法分为试验组（51例），常规组（51例）。常规组进行NB-UVB治疗，试验组采用NB-UVB联合左西替利嗪治疗。治疗结束后评估患儿临床效果，比较治疗前后特应性皮炎评分（SCORAD）及EOS、血清总IgE变化情况，统计比较治疗期间的不良反应发生情况。结果：试验组、常规组治疗总有效率分别为94.12%、78.43%，试验组较常规组高，差异有统计学意义（P<0.05）。治疗后，两组SCORAD较治疗前均降低，试验组较常规组低（P<0.05）。治疗前，两组血清EOS、IgE水平对比，差异均无统计学意义（P>0.05）；治疗后，两组血清EOS、IgE水平均较治疗前降低，试验组均较常规组低（P<0.05）。两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：NB-UVB联合左西替利嗪能够提高特应性皮炎患儿的临床效果，促进患儿恢复，降低血清EOS、IgE水平，安全性较高。

【关键词】 左西替利嗪 不良反应 特应性皮炎 皮肤发红 嗜酸性粒细胞

Effects of NB-UVB Combined with Levocetirizine on EOS and IgE Levels in Children with Atopic Dermatitis/XIONG Fei， ZHU Kun. //Medical Innovation of China， 2024， 21（15）： 0-037

[Abstract] Objective： To investigate the effects of narrow bound ultra violet B light （NB-UVB） combined with Levocetirizine on eosinophile （EOS） and immunoglobulin E （IgE） levels in children with atopic dermatitis. Method： A total of 102 children with atopic dermatitis admitted to Jiujiang University Affiliated Hospital from January 2020 to June 2023 were selected and divided into experimental group （51 cases） and conventional group （51 cases） according to random number table method. The conventional group was treated with NB-UVB， and the experimental group was treated with NB-UVB combined with Levocetirizine. After treatment， the clinical efficacy of the children was evaluated， and the changes of scoring atopic dermatitis （SCORAD）， EOS and serum total IgE before and after treatment were compared， and the occurrence of adverse reactions during treatment were statistically compared. Result： The total effective rate of the experimental group and the conventional group was 94.12% and 78.43%， respectively， and that in the experimental group was higher than that in the conventional group， the difference was statistically significant （P<0.05）. After treatment， the SCORAD in the two groups were decreased compared to those before treatment， that in the experimental group was lower than that in the conventional group （P<0.05）. There were no significant differences in serum EOS and IgE levels between the two groups before treatment （P>0.05）; after treatment， the serum EOS and IgE levels in both groups were decreased compared to those before treatment， the serum EOS and IgE levels in the experimental group were lower than those in the conventional group （P<0.05）. There was no significant difference in the incidence of adverse reaction between the two groups （P>0.05）. Conclusion： NB-UVB combined with Levocetirizine can improve the clinical efficacy of children with atopic dermatitis， promote recovery， reduce serum EOS and IgE levels， and have high safety.

[Key words] Levocetirizine Adverse reactions Atopic dermatitis Skin redness Eosinophils

First-author's address： Department of Dermatology， Jiujiang University Affiliated Hospital， Jiujiang 332000， China

doi：10.3969/j.issn.1674-4985.2024.15.008

特应性皮炎是儿童时期最常见的变态反应性疾病之一，在发达国家发病率高于发展中国家[1]。近年来，随着我国经济的发展及生活方式的不断西化，我国国民超敏性体质人群明显增多，特应性皮炎发病率随之升高，超过15%的儿童均受到过特应性皮炎影响，现已成为危害性较大的一种异质性皮肤病[2]。特应性皮炎可累及脸、颈、肘窝、腘窝、膝窝及四肢背后等多个部位，以红斑、丘疹及苔藓样变等为主要皮损表现，可相互融合成片或分散状分布，伴随强烈瘙痒，患处多因搔抓破损继发细菌感染，形成“瘙痒-搔抓”恶性循环。……