裴璐 张新翠 刘宇甄

【摘 要】目的 探討他克莫司软膏与盐酸米诺环素联合治疗玫瑰痤疮的临床效果。方法 选取2021年1月-12月于我院门诊就诊的60例玫瑰痤疮患者为研究对象，以随机数字表法分为观察组和对照组，各30例。对照组采用盐酸米诺环素胶囊口服治疗，观察组在对照组基础上联合他克莫司软膏联合治疗，比较两组皮损情况、主观症状、临床疗效以及不良反应发生率。结果 观察组治疗后轻度占比高于对照组，差异有统计学意义（P<0.05）；观察组治疗后各项症状评分均低于对照组，差异有统计学意义（P<0.05）；观察组治疗总有效率高于对照组，差异有统计学意义（P<0.05）；观察组不良反应发生率高于对照组，但差异无统计学意义（P>0.05）。结论 他克莫斯软膏联合盐酸米诺环素治疗玫瑰痤疮可以取得较好的治疗效果，能够改善患者临床症状，且安全性较高，值得临床应用。

【关键词】他克莫司软膏；盐酸米诺环素；玫瑰痤疮

中图分类号：R758.73+3 文献标识码：A 文章编号：1004-4949（2023）17-0036-04

Clinical Effect of Tacrolimus Ointment Combined with Minocycline Hydrochloride in the Treatment of Rosacea

PEI Lu1， ZHANG Xin-cui1， LIU Yu-zhen2

（1.Department of Integrated Traditional Chinese and Western Medicine， Dermatology Hospital， Chinese Academy of Medical Sciences， Nanjing 210042， Jiangsu， China； 2.Department of Dermatology， Jiangning Hospital， Nanjing 211100， Jiangsu， China）

【Abstract】Objective To investigate the clinical effect of tacrolimus ointment combined with minocycline hydrochloride in the treatment of rosacea. Methods A total of 60 patients with rosacea who were treated in our hospital from January to December 2021 were selected as the research objects. They were divided into observation group and control group by random number table method， with 30 patients in each group. The control group was treated with minocycline hydrochloride capsules orally， and the observation group was treated with tacrolimus ointment on the basis of the control group. The skin lesions， subjective symptoms， clinical efficacy and incidence of adverse reactions were compared between the two groups. Results The mild proportion of the observation group after treatment was higher than that of the control group， and the difference was statistically significant （P<0.05）. After treatment， the symptom scores of the observation group were lower than those of the control group， and the difference was statistically significant （P<0.05）. The total effective rate of the observation group was higher than that of the control group， and the difference was statistically significant （P<0.05）. The incidence of adverse reactions in the observation group was higher than that in the control group， but the difference was not statistically significant （P>0.05）. Conclusion Tacrolimus ointment combined with minocycline hydrochloride in the treatment of rosacea can achieve better therapeutic effect， improve the clinical symptoms， and has high safety， which is worthy of clinical application.

【Key words】Tacrolimus ointment； Minocycline hydrochloride； Rosacea

玫瑰痤疮（rosacea）是一种临床常见的慢性炎性皮肤病，多出现于患者面中部隆突部位，且女性患病率高于男性，但男性临床症状多较女性严重[1]。对于玫瑰痤疮的治疗，临床治疗目标是缓解或消除临床症状，减少或减轻复发，提高患者生活质量[2-4]。在系统性治疗中，盐酸米诺环素是主要治疗药物之一，它虽然属于广谱抗生素，用于治疗各类浅表性化脓性感染，但同时具有抗炎作用，对多种炎症性皮肤病具有良好的疗效。他克莫司是一种具有大环内酯结构的免疫抑制剂，其软膏制剂可有效治疗脂溢性皮炎、特应性皮炎、白癜风等[5，6]。玫瑰痤疮是与天然免疫功能失调等因素相关的炎症性皮肤病，米诺环素联合外用他克莫司具有良好的抗炎和免疫调节功能。……