新生儿病理性黄疸对甲状腺功能的影响探究
2021-11-11张美华
张美华


【摘要】目的:就新生儿病理性黄疸对甲状腺功能的影响予以探究分析。方法:纳入2019年4月至2020年9月于我院妇产科分娩的29例病理性黄疸新生儿为研究组,纳入同一时段内分娩的29例生理性黄疸新生儿为对照组,为两组新生进行肝功能检测以及甲状腺功能检测,分析各自检测结果。结果:比较两组ALT(丙氨酸转移酶)、AST(天门冬氨酸转移酶)指标水平,研究组各项指标水平较对照组更高,指标对比差异显示出统计学价值(P<0.05);比较甲状腺功能检测水平,两组T3(血清三碘甲状腺原氨酸)、FT3(游离三碘甲状腺氨酸)以及T4(甲状腺素)、FT4(游离甲状腺素)指标水平对比差异不明显,不存在统计学价值(P>0.05),两组TSH(血清促甲状腺素)指标水平对比差异强烈,指标对比差异显示出统计学价值(P<0.05)。结论:新生儿病理性黄疸可使肝细胞出现不同程度损伤,其灭活促甲状腺激素能力减弱,可进一步提升促甲状腺激素水平。
【关键词】病理性黄疸;甲状腺功能;肝功能
【中图分类号】R722.1 【文献标识码】A 【DOI】10.12332/j.issn.2095-6525.2021.15.019
【Abstract】Objective:To investigate and analyze the effect of neonatal pathological jaundice on thyroid function. Methods: in April 2019 to September 2020 in 29 cases of pathological jaundice newborn obstetrics and gynecology hospital team, in the same period as the control group, 29 cases of physiological jaundice newborn for two groups of new liver function tests and thyroid function tests, analyzing their test results results: compare two groups of ALT (alanine transferase) AST(aspartate transferase) levels in the study group were higher than those in the control group, and the difference of indicators showed statistical value (P<0.05). Comparison of thyroid function test levels, T3(serum triiodothyroxine) FT3(free triiodothyroxine) and T4(thyroxine) between the two groups There was no significant difference in FT4(free thyroxine) index level between the two groups, which showed no statistical value (P>0.05). There was a strong difference in TSH(serum thyrotropin) index level between the two groups, which showed statistical value (P<0.05). Conclusion: Neonatal pathological jaundice can cause different degrees of damage to liver cells, and its ability to inactivate thyroid hormone is weakened, which can further enhance the level of thyroid hormone. Keywords pathological jaundice; Thyroid function; Liver function.
【Key words】Pathologic jaundice; thyroid function; liver function
作為人体重要内分泌器官,甲状腺常见疾病包括甲状腺功能亢进、甲状腺功能减退,前者由甲状腺激素产生过多引起,后者由甲状腺激素不足引起,但其都会影响人体心血管、消化、生殖以及神经等系统。而甲状腺激素可作用于人体几乎全部细胞,对于婴儿而言,其是促进骨骼、脑以及生殖器官生长发育的重要因素,对维持神经系统的兴奋性亦具有重要意义[1]。故先天性甲状腺功能减低症已成为我国新生儿疾病筛查重要内容之一。……
