邵帅 万雪晶 吴悦 齐美双

摘要：目的 探讨泮托拉唑联合胃镜喷洒血凝酶治疗消化性溃疡合并出血（PUB）的临床价值。方法 将70例于2020年3月-2021年3月收治的PUB患者纳入研究，并以等量电脑随机法均分成AB两组。均予以两组泮托拉唑治疗，B组添加胃镜喷洒血凝酶治疗，并对比疗效。结果 B组止血时间及出血量均低于A组，临床疗效高于A组，对比有统计学意义（P〈0.05）。结论 泮托拉唑联合胃镜喷洒血凝酶治疗PUB疗效确切，可加快止血，并降低出血量，对预后质量起到积极促进作用，临床应用价值较高，值得推广。

关键词：泮托拉唑;胃镜;血凝酶;消化性溃疡合并出血

Objective to investigate the clinical value of pantoprazole combined with gastroscopy with coagulase in the treatment of peptic ulcer complicated with bleeding（PUB）. Methods 70 patients with pub who were treated from March 2020 to March 2021 were enrolled in the study，and the patients were divided into two groups by the same amount of computer random method. Both groups were treated with pantoprazole，group B was treated with gastroscope and coagulase，and the curative effect was compared. Results the hemostasis time and bleeding volume of group B were lower than that of group A，and the clinical effect was higher than that of group A（P < 0.05）. Conclusion pantoprazole combined with gastroscopy with hemagglutinase has a definite effect on pub，which can accelerate hemostasis and reduce the bleeding volume，and play a positive role in promoting the quality of prognosis. It is of high clinical value and worth popularizing.

[Key words]pantoprazole;Gastroscope;Hemagglutinase;Peptic ulcer with bleeding

消化性溃疡是临床上常见疾病，作为溃疡的四大并发症，其中第一就是消化道出血，发生率非常高，可以达到25%【1】。对于消化道溃疡出血患者使用止血药，实际上意义并不大，更重要的是应用抑制胃酸药物，把胃酸环境降下来，让血凝块不受胃酸的作用而溶解【2】。同时可通过急诊胃镜观看到溃疡出血，并在局部通过喷洒缩血管药物达到止血的目的【3】。而本次纳入研究PUB患者70例，并于2020年3月-2021年3月开展医学研究，着重分析泮托拉唑与胃镜喷洒血凝酶的联合疗效。现将详细内容进行如下报告：

1 资料和方法

1.1一般资料

经院内伦理委员会批准，将70例于2020年3月-2021年3月收治的PUB患者纳入研究，并以等量电脑随机法均分成AB两组，且均签署知情文件。同时排除年龄≤18岁、沟通及精神异常、药敏史、依从性较差患者。男女比例A组20：15，B组18：17;平均年龄A组（37.65±3.54）岁，B组（37.15±3.61）;平均溃疡面积A组（1.21±0.54）cm，B组（1.17±0.60）cm。……