陈桂云

摘要：目的 对比分析冠心病慢性心力衰竭选择不同剂量阿托伐他汀钙用药方案的临床效果。方法 72例研究对象，计算机随机均分两组。两组均接受常规对症治疗，对照组联合小剂量（20mg）阿托伐他汀治疗，观察组联合大剂量（40mg）阿托伐他汀治疗，对比两组临床效果差异性。结果 观察组治疗有效率高于对照组，治疗后心功能指标均优于对照组（P<0.05）;两组治疗阶段不良事件发生率无明显差异（P>0.05）。结论 冠心病慢性心力衰竭常规治疗同时联合大剂量（40mg/d）阿托伐他汀钙治疗可提升治疗有效性，促进心功能改善，且不会增加不良事件发生率，效果理想。

关键词：冠心病;慢性心力衰;剂量;阿托伐他汀钙

[Abstract]Objective To compare and analyze the clinical effect of different doses of atorvastatin calcium in patients with coronary heart disease and chronic heart failure. Methods 72 patients were randomly divided into two groups. Both groups received conventional symptomatic treatment，the control group combined with low-dose（20mg）atorvastatin treatment，the observation group combined with high-dose（40mg）atorvastatin treatment，the difference of clinical effect between the two groups was compared. Results the effective rate of the observation group was higher than that of the control group，and the cardiac function indexes of the observation group were better than those of the control group after treatment（P < 0.05）;There was no significant difference in the incidence of adverse events between the two groups（P > 0.05）. Conclusion conventional treatment combined with high-dose（40mg / D）atorvastatin calcium in the treatment of coronary heart disease with chronic heart failure can improve the treatment effectiveness，promote the improvement of cardiac function，and will not increase the incidence of adverse events，the effect is ideal.

[Key words]coronary heart disease;Chronic heart failure;Dose;Atorvastatin calcium

冠心病也被称为缺血性心脏病，致病原因为患者的脂质代谢异常导致心肌坏死或发生心肌供血不足，当心脏排血量无法供给全身血液循环需要时，就会发生心力衰竭【1-3】。中老年人为冠心病心力衰竭的高发人群，不但会对患者生活质量造成严重影响，甚至会危及生命。临床通常选择药物对症治疗，常规方法效果有待增强【4】。本次研究常规治疗冠心病慢性心力衰同时，使用不同计量阿托伐他汀钙进行联合治疗，对比不同给药计量的临床效果差异，为疾病临床治疗提供更多参考依据。现报道如下。

1 资料与方法

1.1 一般资料

选取2020年1月-2020年12月本院收治的72例冠心病慢性心力衰竭患者为研究对象，计算机随机均分两组。对照组，男20例，女16例，年龄40-76岁，平均（54.21±3.26）岁。观察组，男19例，女17例，年龄43-75岁，平均（54.37±3.42）岁。……